NexGard Combo for Cats

NexGard Combo is a monthly topical solution for cats. It provides comprehensive protection against fleas, ticks, heartworm disease, and intestinal worms. The active ingredients include esafoxolaner, eprinomectin, and praziquantel. Safe for kittens as young as 8 weeks old and weighing as little as 1.8 pounds.

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This product has multiple variants. The options may be chosen on the product page

NEXGARD Combo for Cats

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) offers comprehensive protection for cats. This unique, broad-spectrum parasite treatment is the first of its kind, designed specifically for cats. It effectively kills fleas and ticks, prevents heartworm disease, and treats roundworms, hookworms, and tapeworms. Whether your cat is an indoor or outdoor pet, NexGard COMBO provides the essential parasite protection they need.

Active Ingredients and Their Functions

  • Esafoxolaner: An insecticide and acaricide that effectively kills fleas and ticks. It works by interfering with the nervous system of these parasites, leading to their death.
  • Eprinomectin: An antiparasitic agent that targets various internal parasites, including roundworms and hookworms. It paralyzes and eventually kills these parasites.
  • Praziquantel: An anthelmintic specifically effective against tapeworms. It disrupts the parasite’s ability to maintain its position in the intestines, leading to their expulsion from the cat’s body.

Benefits of NEXGARD Combo for Cats

  • Comprehensive Protection: Offers broad-spectrum protection against fleas, ticks, roundworms, hookworms, and tapeworms.
  • Convenient Administration: Available in an easy-to-use topical solution that is applied to the cat’s skin.
  • Fast-Acting: Starts working quickly to kill fleas and ticks, providing immediate relief for your cat.
  • Long-Lasting: Provides protection for a full month with just one application.
  • Safe for Cats: Formulated specifically for feline use, ensuring safety and efficacy.

Usage Instructions

  • Dosage: Follow the recommended dosage based on your cat’s weight. Consult the product packaging or your veterinarian for specific dosing guidelines.
  • Application: Part the cat’s fur at the base of the neck and apply the entire contents of the applicator directly onto the skin. Ensure the solution is applied in a single spot to minimize the chance of the cat licking it off.
  • Frequency: Apply once a month for continuous protection against parasites.

Precautions and Side Effects

  • Consult Your Veterinarian: Before using NEXGARD Combo, consult with your veterinarian, especially if your cat has any underlying health conditions or is on other medications.
  • Observe for Reactions: Monitor your cat for any adverse reactions after application. Common side effects may include mild skin irritation at the application site. If you notice any severe reactions, contact your veterinarian immediately.
  • Avoid Ingestion: Prevent your cat from licking the application site until it is dry to avoid ingestion of the product.

NEXGARD Combo for Cats offers a reliable and convenient solution for protecting your cat against a wide range of parasites. With its easy-to-apply topical formulation and broad-spectrum efficacy, it helps ensure your feline friend remains healthy and free from the discomfort and risks associated with parasitic infestations. Always follow the product instructions and consult your veterinarian to ensure the best care for your pet.


Is NexGard COMBO topical solution safe for my cat?

 Yes, NexGard COMBO is safe for cats when used as directed. It has been specifically formulated and tested to ensure safety and efficacy for feline use.

Can NexGard COMBO topical solution be used in breeding, pregnant, or lactating cats? 

Consult your veterinarian before using NexGard COMBO in breeding, pregnant, or lactating cats to ensure it is appropriate for your pet’s specific condition.

Is there a weight or age requirement to give my cat NexGard COMBO topical solution? 

NexGard COMBO is generally safe for cats and kittens that weigh at least 1.8 pounds and are 8 weeks of age or older. Always follow the product’s guidelines and consult your veterinarian.

How long does a dose of NexGard COMBO topical solution last and how often should I treat my cat? 

One dose of NexGard COMBO lasts for one month. You should treat your cat once a month to ensure continuous protection against parasites.

How do I apply NexGard COMBO topical solution to my cat?

  • Part the fur at the base of the cat’s neck.
  • Apply the entire contents of the applicator directly onto the skin.
  • Ensure the solution is applied in one spot to minimize the chance of the cat licking it off.

Can I start treating my cat with NexGard COMBO topical solution at any time during the year? 

Yes, you can start treating your cat with NexGard COMBO at any time during the year. Consistent monthly treatments are recommended for continuous protection.

How does NexGard COMBO topical solution work?

NexGard COMBO topical solution offers comprehensive protection against a wide range of parasites. Its three active ingredients – esafoxolaner, eprinomectin, and praziquantel – effectively eliminate fleas and ticks, prevent heartworm disease, and treat and control roundworms, hookworms, and tapeworms.

Can NexGard COMBO topical solution be used with other medications? 

Consult your veterinarian before combining NexGard COMBO with other medications to ensure safety and avoid potential interactions.