Credelio Plus for Dogs
No Prescription Required

Credelio Plus is a monthly oral chewable containing lotilaner and milbemycin oxime, covering fleas, ticks, heartworm, roundworms, hookworms and whipworm in a single tablet. It is approved for dogs and puppies from 8 weeks of age weighing at least 1.4 kg, available in five weight-based pack sizes ranging from 1.4 kg to 45 kg.

Available through Anipetshop without a veterinary prescription, this product is dispensed under Australian APVMA regulations, where it is classified as an over-the-counter parasiticide. The lotilaner and milbemycin oxime formulation supplied matches the active ingredients, strength, and dosing protocol of the prescription-only equivalent in the European, ensuring consistent pharmacological efficacy and safety.

Can You Buy Credelio Plus Without a Vet Prescription?

Yes. Credelio Plus can be obtained without a veterinary prescription through Anipetshop, a licensed online pharmacy operating in compliance with Australian APVMA regulations.

Whether a prescription is required depends on the regulatory classification of the medication in the country of dispensing, not the country of the buyer. Credelio Plus is authorized in the European Union under the European Medicines Agency (EMA) framework, where it is classified as a prescription-only veterinary medicine under EU Regulation 2019/6.

Australia’s APVMA classifies Credelio Plus as an over-the-counter product. Anipetshop is based in Noosaville, Queensland, and operates under APVMA jurisdiction, which permits the dispensing of Credelio Plus without a prescription to both domestic and international customers, including those in the U.S. and Canada. The lotilaner and milbemycin oxime formulation supplied through Anipetshop uses the same active ingredients and dosage standards as the EU authorized products.

Explore the Chewable Tablet Formulation

Credelio Plus is a monthly oral chewable containing two active ingredients: lotilaner (isoxazoline class) for flea and tick control, and milbemycin oxime (macrocyclic lactone class) for heartworm and intestinal worm prevention. Each tablet is sized and dosed to a specific weight band, so the concentration of both actives scales with the dog’s body weight.

The physical composition of each tablet is as follows:

• Flavoring: Meat-flavored chewable tablet designed for high palatability. Most dogs accept the chew voluntarily as a treat, without the need to hide it in their food.
• Inactive excipients: Cellulose, lactose monohydrate, silica, and magnesium stearate serve as binders and stabilizers. These do not contribute to pharmacological activity.
• Physical form: White to beige, round biconvex tablets with a textured surface. The texture aids grip when handling and does not affect absorption.
• Storage requirement: Store at or below 25°C (77°F) in a cool, dry location. Keep out of reach of children and store in the original packaging until use.

Credelio Plus is available in five weight-based pack sizes. Pack color corresponds to weight range and can be used to confirm the correct product at the time of dosing:

Take the Correct Dosage

Credelio Plus dosing is weight-based, with a minimum effective dose of 20 mg lotilaner/kg and 0.75 mg milbemycin oxime/kg body weight. Dosage does not vary by age or breed. Tablets should not be split or crushed, as each chew is formulated to deliver the full labeled dose as a single unit.

Weigh your dog before each monthly dose to confirm the correct weight band, particularly for puppies still gaining weight. A dog that has moved into a higher weight band since the last dose requires the next tablet size up. Administering a lower-band tablet to a heavier dog results in underdosing of both lotilaner and milbemycin oxime.

The table below shows the active ingredient content per tablet for each weight band:

For dogs approaching the upper limit of a weight category, maintain the current dose and only escalate to the next pipette size once the dog’s verified body weight exceeds the threshold at the time of administration. Considering a dog currently weighing 24.5 lbs, the correct tablet is the Orange pack (12.1 to 25.0 lbs). If the same dog weighs 25.3 lbs at the next monthly dose, switch to the Green pack (25.1 to 50.0 lbs). Do not advance to the next weight band until the dog’s confirmed weight at the time of dosing exceeds the upper threshold of the current band.

Dogs over 100 lbs fall outside the labeled single-tablet dosing range. A veterinarian should determine the appropriate multi-tablet regimen for these dogs before treatment begins.

Why Dog Owners Should Choose Credelio Plus

Dog owners choose Credelio Plus because it is the only monthly oral chewable that combines lotilaner and milbemycin oxime in a single tablet, covering fleas, four tick species, heartworm, roundworms, hookworms and whipworm without a separate topical or additional dewormer. Manufacturer efficacy data reports 100% prevention of heartworm disease and over 96.8% efficacy against larval intestinal worms.

The following points outline the clinical performance of each protection category:

• Single tablet replaces multiple products. Lotilaner addresses external parasites while milbemycin oxime addresses internal parasites in one monthly dose. Dogs on Credelio Plus do not require a separate heartworm preventive or intestinal wormer.
• Flea kill begins within 4 hours. Lotilaner reaches pharmacologically active blood concentrations rapidly after oral dosing. Manufacturer data shows near-complete flea elimination within 12 hours of the first dose.
• Tick elimination within 48 hours. Credelio Plus is labeled for black-legged ticks, American dog ticks, brown dog ticks, and lone star ticks. Lotilaner’s inhibition of GABA-gated chloride channels causes paralysis and death in feeding ticks within 48 hours.
• Heartworm and intestinal worm coverage via milbemycin oxime. Milbemycin oxime eliminates Dirofilaria immitis larvae, Toxocara canis (roundworm), and Ancylostoma caninum (hookworm) by increasing chloride ion permeability across parasite nerve cell membranes, causing paralysis.
• Approved from 8 weeks of age. Credelio Plus is labeled for puppies weighing at least 1.4 kg (approximately 3 lbs) from 8 weeks of age. Early dosing establishes heartworm prevention before the first mosquito exposure window.

How Do Pet Owners Review Non-Prescription Credelio Plus Online?

Pet owners purchasing Credelio Plus through Anipetshop most commonly report three observations: dogs accept the chew without resistance, flea activity decreases visibly within the first treatment cycle, and the out-of-pocket cost is lower than purchasing through a European veterinary clinic.

Reviewers in flea-prone households report a noticeable reduction in flea activity within 24 to 48 hours of the first dose, which is consistent with lotilaner’s labeled speed of kill. The meat-flavored and hydrolyzed soy flavoring is frequently noted as a factor in voluntary acceptance. Repeat purchasers cite the ability to order without a prescription as a practical factor in maintaining a consistent monthly dosing schedule.

Order Credelio Plus for Dogs Without a Vet Prescription at AnipetShop

Credelio Plus is available through Anipetshop without a veterinary prescription. All stock is sourced directly from original manufacturers and carries English-language labeling with the same active ingredient concentrations and dosage standards as the prescription product dispensed in the European.

The following points describe the sourcing and product standards that apply to all Credelio Plus orders through Anipetshop:

• Original manufacturer sourcing. Stock is supplied from licensed manufacturers across Australia and Europe. No generic or substitute formulations are stocked.
• Active ingredient equivalence. Lotilaner and milbemycin oxime concentrations match the labeled dosage standards of the EU prescription product. Formulation, inactive excipients, and dosage per weight band are identical.
• English-language labeling. All packaging includes full English labeling covering dosage instructions, contraindications, and storage requirements. This allows accurate dosing without reference to a translated or adapted label.
• Shelf life at time of dispatch. Products are dispatched with sufficient remaining shelf life to complete the purchased supply without potency loss.

How Credelio Plus Works on Dogs

Credelio Plus contains two active ingredients, lotilaner and milbemycin oxime, both absorbed orally and distributed systemically through the bloodstream. Each ingredient targets a distinct parasite group through a different neurological mechanism. Because both act systemically rather than topically, parasites are exposed to the active ingredient only when they bite or feed.

Lotilaner

Lotilaner is an isoxazoline-class insecticide and acaricide, and the active ingredient in Credelio (manufactured by Elanco). It acts as a potent inhibitor of GABA-gated chloride channels in insects and ticks, with secondary inhibitory activity on glutamate-gated chloride ion channels. This dual channel blockade disrupts normal neurotransmission in the parasite’s nervous system, causing rapid paralysis and death. Lotilaner is formulated as a pure enantiomer, which means it is a single stereoisomeric form rather than a racemic mixture, contributing to its targeted activity against fleas, adult ticks, and certain mite species.

Milbemycin Oxime

Milbemycin oxime is a macrocyclic lactone derived from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus, and is the active ingredient in products such as Interceptor and, in combination with other actives, Sentinel and Credelio Plus. It consists of two primary factors, A3 and A4, in an approximate 20:80 ratio. Milbemycin oxime is an endectocide with activity against larval stages L4 and L5 as well as adult nematodes, and against L3 and L4 larvae of Dirofilaria immitis, the heartworm parasite.

Its mechanism of action targets invertebrate neurotransmission. Milbemycin oxime increases nematode and insect cell membrane permeability to chloride ions by binding to glutamate-gated chloride ion channels, a mechanism shared with avermectins and other milbemycins. The resulting chloride influx hyperpolarizes the neuromuscular membrane, producing flaccid paralysis and death of the parasite. This channel type is absent in mammals, which accounts for the selective toxicity profile in dogs and cats at labeled doses.

Flea elimination before reproductive maturity disrupts the flea life cycle at the adult stage. Consistent monthly dosing progressively reduces environmental flea burden by preventing egg deposition from surviving adults.

How Should You Administer Credelio Plus?

Credelio Plus should be given orally with food or within 30 minutes after a meal. Co-administration with food increases gastrointestinal absorption of lotilaner, which is required to reach pharmacologically active blood concentrations. Administering on an empty stomach reduces bioavailability and may result in subtherapeutic plasma levels.

Before the first dose, confirm that your dog has tested negative for heartworm. Administering milbemycin oxime to a heartworm-positive dog can cause a rapid die-off reaction from circulating microfilariae. A veterinarian should perform the heartworm test and advise on timing of the first dose if the dog’s status is unknown.

The following steps apply to each monthly dose:

1. Select by weight. Confirm your dog’s current weight before each dose and match it to the correct weight band. A dog weighing 24 lbs (10.9 kg) requires the Orange pack (225 mg lotilaner / 8.44 mg milbemycin oxime), while a dog weighing 27 lbs (12.2 kg) requires the Green pack (450 mg lotilaner / 16.88 mg milbemycin oxime). Do not use the previous month’s weight for a growing puppy.
2. Administer with food. Give the tablet during or immediately after a meal to ensure adequate absorption.
3. If the dog refuses the chew. Place the tablet in a small amount of food. If the dog still resists, place the tablet directly at the back of the tongue and hold the mouth closed until swallowed.
4. Confirm full ingestion. Watch for complete swallowing before ending supervision. If vomiting occurs within one hour of dosing, administer a full replacement dose with food.
5. Maintain the monthly interval. Dose on the same calendar date each month. Gaps longer than 30 days leave the dog unprotected against heartworm larvae acquired during that period.

In heartworm-endemic regions, the first dose should be given within one month of the start of mosquito season and continued monthly until at least one month after the end of mosquito exposure.

Are There Any Side Effects of Credelio Plus to Consider?

Adverse reactions are documented and should be reviewed before starting treatment although Credelio Plus is tolerated by most dogs at labeled doses. Side effects fall into two categories: gastrointestinal reactions common to oral parasiticides, and neurological reactions specific to the isoxazoline drug class.

The following gastrointestinal and dermal reactions have been reported, typically appearing within hours of dosing and resolving without intervention:

• Vomiting or diarrhea. The most commonly reported reactions after oral dosing. If vomiting occurs within one hour of administration, redose with food.
• Reduced appetite. Transient decrease in food intake lasting one to two days post-dose.
• Lethargy. Mild reduction in activity for one to two days. Persistent lethargy beyond 48 hours warrants veterinary assessment.
• Skin reactions. Localized itching or erythema at irregular intervals post-dose.

As an isoxazoline-class medication, Credelio Plus carries warning for the following neurological adverse events, which can occur in dogs with no prior history of neurological disease:

• Muscle tremors. Involuntary muscle contractions, ranging from mild twitching to sustained tremor episodes.
• Ataxia. Loss of coordinated movement. Affected dogs may appear unsteady or unable to walk normally.
• Seizures. Reported across the isoxazoline class including lotilaner. Dogs with a history of seizures or neurological conditions are at elevated risk. A veterinarian should assess these dogs before Credelio Plus is initiated.

Are There Credelio Plus Alternatives That Don’t Require a Vet’s Prescription?

Yes, several broad-spectrum parasite treatments are available without a veterinary prescription through Anipetshop. These cover combinations of fleas, ticks, heartworm, and intestinal worms using isoxazoline or macrocyclic lactone active ingredients. No alternative product combines lotilaner and milbemycin oxime in a single monthly chewable.

The following alternatives are available and differ from Credelio Plus in active ingredient composition and parasite coverage:

• NexGard Spectra (afoxolaner + milbemycin oxime). Covers fleas, ticks, heartworm, roundworms, hookworms and whipworm. Afoxolaner is an isoxazoline; the flea and tick coverage profile differs from lotilaner in speed of kill data.
• Simparica Trio (sarolaner + moxidectin + pyrantel). Covers fleas, ticks, heartworm, roundworms and hookworms. Sarolaner is an isoxazoline; moxidectin replaces milbemycin oxime as the macrocyclic lactone component.
• Heartgard Plus (ivermectin + pyrantel). Covers heartworm, roundworms, and hookworms only. Does not provide flea or tick coverage. Ivermectin is contraindicated in MDR1-affected breeds including Collies, Australian Shepherds, and related herding breeds.

Product selection should be based on the parasite species present in the dog’s environment, the dog’s weight, breed, and health history. A veterinarian can confirm which active ingredients are appropriate for individual dogs with known sensitivities or breed-related drug metabolism differences.

FAQs

What is the difference between Credelio and Credelio Plus?

Credelio contains lotilaner only and covers fleas and ticks. Credelio Plus adds milbemycin oxime to the formulation, extending coverage to heartworm (Dirofilaria immitis), roundworms (Toxocara canis), hookworms (Ancylostoma caninum), and whipworms (Trichuris vulpis).

How should I give Credelio Plus to my dog?

Administer one tablet orally once a month, during or within 30 minutes after a meal. Co-administration with food is required for adequate lotilaner absorption. The meat-flavored and hydrolyzed soy flavoring is accepted voluntarily by most dogs, but the tablet can be placed in food if the dog resists.

What if my dog misses a dose?

If fewer than 14 days have passed since the missed dose, administer it immediately with food and resume the regular monthly schedule from that date. If more than 14 days have passed, the gap in milbemycin oxime coverage may be sufficient for heartworm larvae acquired during that period to mature. A veterinarian should assess whether heartworm testing is needed before resuming treatment.

What if my dog vomits after taking Credelio Plus?

If vomiting occurs within one hour of dosing, administer a full replacement dose with food. Vomiting within this window indicates the tablet was not fully absorbed.

Can puppies take Credelio Plus?

Credelio Plus is approved for puppies from 8 weeks of age weighing at least 1.4 kg. The minimum weight threshold applies regardless of age: a puppy that has reached 8 weeks but weighs less than 1.4 kg should not receive the product until the weight threshold is met.

How quickly does Credelio Plus start working?

Lotilaner begins killing fleas within 4 hours of dosing, with near-complete flea elimination within 12 hours. Tick elimination occurs within 48 hours. Milbemycin oxime prevents heartworm larval development from the first dose onward when given within the labeled dosing interval.

Is Credelio Plus safe for pregnant or breeding dogs?

Safety in pregnant, breeding, or lactating dogs has not been established in controlled studies. A veterinarian should evaluate the risk-benefit profile before use in these animals.

How does Credelio Plus compare to NexGard Spectra?

Both products combine an isoxazoline with milbemycin oxime and cover fleas, ticks, heartworm, roundworms, and hookworms in a single monthly oral chew. Credelio Plus uses lotilaner; NexGard Spectra uses afoxolaner. The two isoxazolines share the same mechanism of GABA-gated chloride channel inhibition but differ in pharmacokinetic profiles and labeled speed-of-kill data. Neither product is appropriate for dogs with a history of seizures without prior veterinary assessment.

How does Credelio Plus compare to Simparica Trio?

Simparica Trio combines sarolaner (isoxazoline), moxidectin (macrocyclic lactone), and pyrantel and covers fleas, ticks, heartworm, roundworms and hookworms. Credelio Plus uses milbemycin oxime rather than moxidectin as its macrocyclic lactone component and does not include pyrantel. Both are monthly oral chewables available without prescription through Anipetshop. Dogs with seizure history require veterinary assessment before starting either product due to the isoxazoline component.

How does Credelio Plus compare to Heartgard Plus?

Heartgard Plus contains ivermectin and pyrantel and covers heartworm, roundworms, and hookworms only. It does not provide flea or tick coverage. Credelio Plus covers all of the above parasite categories plus ticks and fleas in a single tablet. Ivermectin in Heartgard Plus is contraindicated in MDR1-affected breeds including Collies, Shetland Sheepdogs, Australian Shepherds, and related herding breeds. Lotilaner and milbemycin oxime in Credelio Plus do not carry the same MDR1 restriction, though individual breed sensitivities should be confirmed with a veterinarian.