Revolution Plus for Cats
No Prescription Required

Revolution Plus is a monthly topical parasiticide for cats, manufactured by Zoetis, combining two active ingredients: selamectin, a macrocyclic lactone, and sarolaner, an isoxazoline. Together, these two compounds deliver systemic protection against fleas, ticks, heartworm larvae, ear mites, roundworms, and hookworms in a single monthly application. Anipetshop supplies Revolution Plus under APVMA regulations, which classify the product as an over-the-counter veterinary medication in Australia. The active ingredients, concentrations, and dosing standards are identical to those in the prescription-only formulation dispensed in the United States.

Can You Buy Revolution Plus for Cats Without a Vet Prescription?

Yes. US pet owners can purchase Revolution Plus for cats without a vet prescription from Anipetshop, an Australian-licensed online pharmacy operating under APVMA regulations.

Whether a prescription is required depends on the regulatory classification of the product in the country of dispensing, not the country of the buyer. In the United States, the FDA classifies Revolution Plus as a prescription-only veterinary drug, requiring authorization from a licensed veterinarian before any US retailer can dispense it. Meanwhile, Australia’s APVMA applies a different classification framework, under which Revolution Plus is registered as an over-the-counter veterinary medication, and no prescription is required for licensed pharmacies to supply it.

As Anipetshop operates under Australian APVMA regulations, it can legally supply Revolution Plus to US customers without a vet prescription. The formulation dispensed through Anipetshop contains the same active ingredients, selamectin and sarolaner, at the same concentrations as the prescription-only product available in the US. All stock is sourced from the original manufacturer, Zoetis, with no alteration to active ingredients, dosage standards, or product specifications.

Explore the Topical Solution Formulation

Revolution Plus for cats is available exclusively as a topical solution, applied once monthly to the skin at a single spot on the back of the neck. The formulation is unscented and contains no oral components. It is absorbed systemically through the skin, which is how selamectin and sarolaner reach the bloodstream to act against parasites.

The following specifications apply to all three weight variants of Revolution Plus for cats:

• Flavoring: None. Revolution Plus is a topical solution applied to the skin, not administered orally, so no flavoring agent is included in the formulation.
• Key excipients: Dipropylene Glycol Monomethyl Ether, Isopropyl Alcohol, and Butylated Hydroxytoluene.
• Physical form: Colorless to yellow clear liquid dispensed in single-dose applicator tubes. Cap color varies by weight range: Yellow for 2.8 to 5.5 lbs, Orange for 5.6 to 11.0 lbs, and Green for 11.1 to 22.0 lbs.
• Storage: Store at controlled room temperature between 59 and 86°F (15 to 30°C), away from heat, open flames, and sparks. Keep out of reach of children.

The three weight-based variants available through Anipetshop are listed below with current pricing:

Product	Price for 3 Doses	Price for 6 Doses	Price for 12 Doses	Pack Color
Revolution Plus for Cats 2.8–5.5 lbs (1.25–2.5 kg)	$59.00	$110.00	$200.00	Yellow
Revolution Plus for Cats 5.6–11.0 lbs (2.6–5.0 kg)	$62.00	$116.00	$228.00	Orange
Revolution Plus for Cats 11.1–22.0 lbs (5.1–10.0 kg)	$68.00	$120.00	$213.50	Green

Take the Correct Dosage

Revolution Plus for cats is dosed by body weight, with three weight-based formulations each delivering a minimum of 2.7 mg/lb (6 mg/kg) selamectin and 0.45 mg/lb (1.0 mg/kg) sarolaner per dose. Weight, not age or breed, determines which tube to use.

The table below shows the correct tube, volume, and active ingredient quantities for each weight range:

Weight Range	Volume	Selamectin	Sarolaner	Tube Color
2.8–5.5 lbs (1.25–2.5 kg)	0.25 ml	15 mg	2.5 mg	Yellow
5.6–11.0 lbs (2.6–5.0 kg)	0.50 ml	30 mg	5.0 mg	Orange
11.1–22.0 lbs (5.1–10.0 kg)	1.00 ml	60 mg	10.0 mg	Green

Cats whose weight falls near the upper boundary of a range should remain in that range rather than advancing to the next tube size. For example, a cat weighing 5.4 lbs falls within the yellow tube range (2.8 to 5.5 lbs) and should receive the yellow tube. That range is calibrated to deliver at least the minimum required dose across the full span of weights it covers. Moving to the next tube size before the upper limit is reached results in overdosing relative to the labeled dose for that weight.

Cats exceeding 22.0 lbs should be dosed using a combination of two tubes to cover total body weight, as specified in the official Zoetis dosage guidelines. Consult a veterinarian if you are uncertain which combination applies to your cat’s current weight.

Why Cat Owners Choose Revolution Plus Over Other Parasite Treatments

Revolution Plus covers six parasite categories in a single monthly application: fleas, ticks, heartworm larvae, ear mites, roundworms, and hookworms. Most single-ingredient topical products address either external parasites or internal worms, not both. The dual-ingredient formulation, selamectin combined with sarolaner, removes the need for a second product to fill coverage gaps.

The following factors distinguish Revolution Plus from other monthly topical options available for cats:

• Tick species coverage: Sarolaner, the isoxazoline component, is labeled to kill four tick species: black-legged tick, American dog tick, Gulf Coast tick, and Lone Star tick. Standard Revolution and Stronghold (selamectin only) carry no tick label for cats.
• Flea kill onset: Revolution Plus begins killing fleas within 6 hours of application. Older pyrethrin-based or fipronil-based topicals reach comparable efficacy more slowly.
• Intestinal worm coverage: Selamectin treats roundworms and hookworms systemically, which eliminates the need for a separate oral dewormer in most routine prevention protocols.
• Age and weight threshold: Revolution Plus is labeled for use in kittens from 8 weeks of age and a minimum body weight of 2.8 lbs. Cats below this weight threshold should not receive the product.
• Indoor cat relevance: Heartworm transmission requires a mosquito vector, and tick exposure can occur through brief outdoor contact or contact with other animals. Indoor-only status does not eliminate exposure risk entirely; consult a veterinarian to assess whether year-round prevention is appropriate for your cat’s living situation.

How Do Pet Owners Review Non-Prescription Revolution Plus For Cats Online?

Pet owners discussing Revolution Plus on forums such as Reddit’s r/CatAdvice report consistent effectiveness as a flea and tick preventative, with several accounts directly comparing it to over-the-counter alternatives.

One user described switching from Revolution Plus to an OTC fipronil-based product after relocating to an area without easy prescription access. Within one month of the switch to the OTC product, her previously flea-free indoor cat developed a flea infestation following a single outdoor outing. She reported no side effects during the period her cat was on Revolution or Revolution Plus, and noted she was returning to Revolution as soon as her new veterinarian could facilitate the prescription. Her assessment was that the added cost and the prescription requirement were justified by the difference in efficacy.

Order Revolution Plus for Cats Without a Vet Prescription at Anipetshop

Anipetshop is an Australian-licensed online pharmacy operating under APVMA regulations, supplying Revolution Plus for cats to US customers without a prescription requirement.

The following points describe the sourcing and product standards that apply to all orders:

• Product authenticity: All Revolution Plus stock is sourced from the original manufacturer. No generic substitutes or repackaged products are supplied.
• Labeling: Products carry clear English labeling consistent with the manufacturer’s original specifications for active ingredients, dosage, and administration.
• Source markets: Stock is sourced from licensed, regulated markets including Australia and Europe, all of which apply manufacturing standards equivalent to those governing the US-marketed product.
• Shelf life: All units are supplied with sufficient remaining shelf life to maintain potency through the labeled use period.
• Regulatory compliance: Anipetshop operates under an Australian pharmacy license issued under APVMA oversight. The absence of a US prescription requirement reflects the difference in OTC classification between Australian and US regulatory frameworks, not a difference in product standards.

How Revolution Plus Works in Cats

Revolution Plus prevents heartworm disease through selamectin, a macrocyclic lactone that targets immature Dirofilaria immitis larvae in the cat’s tissues before they can develop into adult worms. Sarolaner, the isoxazoline component, acts separately against fleas and ticks through a different mechanism. Both compounds reach their target sites via systemic absorption through the skin.

The following describes the mechanism by which selamectin eliminates heartworm larvae after application:

• Systemic absorption: Selamectin is absorbed through the skin into the bloodstream within hours of topical application, distributing to tissues where larvae reside.
• Larval targeting: Selamectin acts against the tissue-stage larvae of Dirofilaria immitis acquired through mosquito bites during the 30 days preceding treatment. It does not eliminate adult heartworms already established in the pulmonary vasculature.
• Neuromuscular paralysis: Selamectin binds to glutamate-gated chloride channels in the larval nervous system, increasing chloride ion conductance and causing irreversible paralysis and death of the larvae.
• Efficacy data: In controlled laboratory studies, a single monthly dose of selamectin at the labeled concentration demonstrated 100% prevention of larval development into adult heartworms.

How to Administer Revolution Plus to Cats

Revolution Plus is applied topically to the skin at the base of the neck, once monthly. Correct application site and skin contact are required for both selamectin and sarolaner to be absorbed systemically. Applying the product onto fur rather than directly to skin reduces absorption and may compromise efficacy against both internal and external parasites.

Follow these steps to administer each dose correctly:

1. Open the tube: Remove the tube from packaging, hold it upright, and press the cap firmly downward until it clicks, puncturing the foil seal. Remove the cap before application.
2. Position the cat: Place the cat in a calm, stable position. Locate the base of the neck just in front of the shoulder blades, a site the cat cannot reach to lick during or after application.
3. Part the fur: Use your fingers to separate the hair until the skin is visible. Applying the solution on top of the coat rather than against the skin will reduce dermal absorption.
4. Apply to skin: Place the tip of the tube against the exposed skin and squeeze firmly three to four times in one spot until the tube is empty. Do not spread the liquid across multiple sites.
5. Allow to dry: Do not rub or massage the application site. Allow the solution to air dry. Do not bathe the cat or allow contact with water for 24 hours following application, as premature washing reduces the amount of active ingredient absorbed through the skin.

After application, keep treated cats away from other pets for at least 4 hours or until the application site is fully dry, as grooming of a wet site can result in another animal ingesting sarolaner and selamectin orally. Do not bathe the cat or allow water contact for 24 hours, since early water exposure reduces dermal absorption of both active compounds.

Never divide a single tube between two cats: sarolaner dosing is weight-dependent, and splitting a tube delivers an unverified quantity to each cat, risking underdosing or exposing a smaller cat to a concentration above the labeled dose for its weight. Do not apply to broken, inflamed, or wounded skin, as a compromised skin barrier alters absorption kinetics and may increase systemic exposure beyond the labeled dose range.

Are There Any Side Effects of Revolution Plus For Cats to Consider?

Revolution Plus contains sarolaner, an isoxazoline-class compound. The FDA has issued a class-wide notice for isoxazolines, including sarolaner, identifying a risk of neurological adverse events across this drug class. Cats with a history of seizures or neurological disorders should not receive Revolution Plus without prior veterinary assessment.

The following side effects have been reported with Revolution Plus use in cats:

• Application site reactions: Temporary hair loss, localised redness, or itching at the application site may occur. These reactions are typically transient and resolve without intervention.
• Gastrointestinal signs: Vomiting or loose stool may occur in the days following application. If gastrointestinal signs persist beyond 48 hours, consult a veterinarian before administering the next dose.
• Lethargy: Reduced activity in the 24 hours following application has been reported. If lethargy extends beyond 24 hours or is accompanied by other signs, seek veterinary advice.
• Hypersalivation: If a cat licks the application site before the solution dries, the bitter excipients in the formulation trigger excessive drooling. This resolves once oral contact with the product ends and does not indicate systemic toxicity in isolation.
• Neurological signs: Muscle tremors, ataxia, and seizures have been reported in cats receiving isoxazoline-class products. These signs require immediate veterinary attention. Do not redose or switch to another isoxazoline product without veterinary clearance.

Are There Revolution Plus For Cats Alternatives That Don’t Require a Vet’s Prescription?

Several topical parasiticides covering heartworm prevention are available for cats without a vet prescription through Anipetshop, under Australian APVMA pharmacy regulations. The products listed below differ from Revolution Plus in active ingredient composition, dosing interval, or parasite coverage scope, and the appropriate choice depends on your cat’s weight, health history, and the parasites present in your region. Consult a veterinarian if you are uncertain which product is suited to your cat’s individual circumstances.

The following alternatives to Revolution Plus are stocked at Anipetshop without a prescription requirement:

• Advocate for cats (imidacloprid + moxidectin): Prevents heartworm larvae and treats fleas, ear mites, roundworms, and hookworms. Available in two weight variants: one for cats under 9 lbs and one for cats over 9 lbs. Advocate does not cover ticks.
• Bravecto Plus for cats (fluralaner + moxidectin): Provides heartworm prevention alongside flea and tick treatment in a single topical dose administered every two months. The extended dosing interval distinguishes it from monthly products such as Revolution Plus, though the two-month window requires that the application date be tracked precisely to avoid a coverage gap.
• NexGard Combo for cats (esafoxolaner + eprinomectin + praziquantel): Covers heartworm prevention, fleas, ticks, roundworms, hookworms, and tapeworms in a single monthly dose. Available in two weight variants: one for cats up to 5.5 lbs and one for cats between 5.5 and 16.5 lbs.
• Stronghold and Stronghold Plus (selamectin; selamectin + sarolaner): Stronghold is the international market equivalent of Revolution, and Stronghold Plus is the equivalent of Revolution Plus, with the same active ingredients at the same concentrations. Both are stocked at Anipetshop without a prescription requirement.

FAQs related to Revolution Plus for Cats

How does Revolution Plus for cats differ from standard Revolution?

Revolution Plus adds sarolaner, an isoxazoline compound, to the selamectin base found in standard Revolution. Sarolaner extends coverage to four tick species and accelerates flea kill onset to within 6 hours of application. Standard Revolution (selamectin only) carries no tick label for cats.

Can a single tube of Revolution Plus be split between two cats?

No. Sarolaner dosing is calibrated by body weight, and dividing a tube produces an unverified quantity for each cat. A smaller cat may receive a sarolaner concentration above the labeled dose for its weight, while the other cat may be underdosed.

How often should Revolution Plus be applied to cats?

Once every 30 days, year-round. Extending the interval beyond 30 days creates a window during which larvae acquired through mosquito bites may escape the selamectin-susceptible tissue stage and progress toward adulthood.

Is it safe to handle the cat after applying Revolution Plus?

Avoid contact with the application site until the solution has dried completely, which takes approximately 2 to 4 hours. Skin contact with wet solution may transfer sarolaner and selamectin to human skin; wash hands if contact occurs.

Is Revolution Plus for cats waterproof?

Revolution Plus is water-resistant from 24 hours after application. Do not bathe the cat or allow water contact within that 24-hour window, as premature water exposure reduces dermal absorption of both active compounds.

What should I do if I miss a monthly dose of Revolution Plus?

Apply the missed dose as soon as it is identified, then resume the 30-day schedule from that new application date. Do not double-dose to compensate for a missed application.

What happens if a cat licks the Revolution Plus application site?

The excipients in the formulation produce a bitter taste that causes hypersalivation. This resolves once oral contact ends and does not indicate systemic toxicity in isolation. If a cat ingests a substantial amount of the solution, contact a veterinarian promptly.

Is Revolution Plus safe for kittens?

Revolution Plus is labeled for use in kittens from 8 weeks of age and a minimum body weight of 2.8 lbs (1.25 kg). Do not use in kittens below either threshold.

Can Revolution Plus be used in pregnant or nursing cats?

The safety of Revolution Plus in breeding, pregnant, or lactating cats has not been fully established in controlled studies. Consult a veterinarian before using this product in a pregnant or nursing cat.

Is Revolution Plus safe for senior cats?

Age alone does not contraindicate Revolution Plus, provided the cat meets the minimum weight requirement and has no history of seizures or neurological disorders. Cats with pre-existing neurological conditions should not receive sarolaner-containing products without prior veterinary assessment, regardless of age.

Does a cat need a heartworm test before starting Revolution Plus?

A veterinarian may recommend a heartworm antigen or antibody test before initiating prevention, particularly if the cat has had potential mosquito exposure and no prior preventative history. Revolution Plus prevents larval development but does not eliminate adult heartworms already present. Starting prevention in a cat with an undetected adult infection does not treat the existing worms.