Nexgard vs Advantage Multi Comparison

Nexgard vs Advantage Multi: Similarities

Both Nexgard and Advantage Multi are designed to protect dogs from harmful parasites, ensuring your pet’s overall health and well-being. Both products offer comprehensive coverage, though they focus on different parasites, making them effective tools in preventing serious infestations.

One of the key similarities is that both Nexgard and Advantage Multi are easy-to-administer treatments. Nexgard comes as a chewable tablet, while Advantage Multi is a topical solution. Both forms are convenient for pet owners to give to their dogs without the stress of more invasive treatments.

Another important similarity is that both products are FDA-approved and have been extensively tested to ensure safety and efficacy. They are widely trusted by veterinarians to control parasites and maintain pets’ health when used as directed. Both treatments are also prescription-based, ensuring that your veterinarian is involved in deciding the best course of treatment for your dog.

What Are the Differences Between Nexgard and Advantage Multi?

Nexgard and Advantage Multi are both effective treatments for parasites, but they differ significantly in their application, targeted parasites, and active ingredients.

Firstly, the mode of administration sets them apart. Nexgard is an oral treatment, delivered as a chewable tablet that is often viewed as a treat by dogs, making it easy to administer. In contrast, Advantage Multi is a topical solution that is applied directly to the skin, which might require more effort if your dog resists topical treatments. Both products provide a month of protection, but the ease of administration could influence your choice based on your dog’s preferences.

The primary difference between the two products lies in the range of parasites they target. Nexgard focuses on fleas and ticks, killing 100% of fleas within 4 hours and eliminating ticks, including black-legged ticks, within 24 hours, which helps in preventing Lyme disease. On the other hand, Advantage Multi offers broader protection, targeting not just fleas, but also heartworms, roundworms, hookworms, whipworms, ear mites, and even some conditions like sarcoptic mange. However, it does not provide protection against ticks.

Another difference is in the active ingredients. Nexgard uses Afoxolaner, which works by disrupting the GABA channels in fleas and ticks, leading to their death. In contrast, Advantage Multi combines Imidacloprid and Moxidectin. Imidacloprid kills fleas, while Moxidectin prevents heartworm and controls a wide range of intestinal worms.

In terms of age and weight restrictions, both treatments can be used at an early age. Nexgard is suitable for puppies as young as 8 weeks, weighing at least 4 lbs, while Advantage Multi can be used for puppies starting at 7 weeks and a minimum of 3 lbs.

Lastly, safety considerations are important when choosing between these treatments. Nexgard has been FDA-approved for flea and tick prevention, but it has not been evaluated for use in breeding, pregnant, or lactating dogs. Advantage Multi has not been established for use in breeding, pregnant, or lactating dogs and it may pose risks for certain breeds, such as collies, which can be sensitive to Moxidectin.

In summary, while both Nexgard and Advantage Multi offer effective flea control, their key differences include the parasites they target, their method of administration, and safety profiles. Nexgard is ideal for dogs needing flea and tick protection in a chewable form, whereas Advantage Multi provides broader parasite control but requires topical application.

The table below offers a side-by-side comparison of Nexgard and Advantage Multi, making it easy to assess their benefits and key differences. By reviewing these features, you can confidently choose the product that best fits your dog’s specific needs.

Feature	Advantage Multi	NexGard
Kills Fleas	Yes	Yes
Repels Fleas	No	No
Kills Flea Eggs and Larvae	No	Kills fleas before they can lay eggs
Kills Ticks	No	Yes
Repels Ticks	No	No
Repels Mosquitoes	No	No
Prevents Heartworm	Yes	No
Protects Against Other Parasites	Ear mites, Roundworms, and Hookworms	No
Waterproof	Yes	Yes – taken orally
How Long to Work	Begins to kill fleas within 12 hours	4 hours to kill fleas and 24 hours to kill ticks
Taste	N/A	Beef flavored
Active Ingredient	Imidacloprid and Moxidectin	Afoxolaner
Application Type	Topical	Chewable Tablet
Dosing	Once per month	1 tablet per month
Age	Dogs 7 weeks and older, weighing at least 3 lbs	Puppies 8 weeks and older, weighing more than 4 lbs
Manufacturer	Bayer Animal Health	Boehringer Ingelheim
Safety	Speak to your vet about risks associated with breeding, pregnant, or lactating dogs	Not yet evaluated for use in breeding, pregnant, or lactating dogs
Side Effects	Depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors	Vomiting, diarrhea, lethargy, rare neurological effects
Duration of Effectiveness	28 days after four monthly treatments	35 days
Price	Moderate per dose	Moderate per dose
Clinical Studies	Demonstrated high effectiveness in clinical trials	Demonstrated high effectiveness in clinical trials
Storage Instructions	Store at room temperature between 39°F and 77°F .	Store at room temperature 30°C (86°F) with excursions permitted up to 40°C (104°F).

To help pet owners make an informed choice, the following table provides pricing details for Nexgard, including different dosages and quantities available at Anipetshop. This breakdown allows you to find the most cost-effective solution for your dog’s parasitic prevention needs.

Product	Dosage	Package Size	Price
NexGard Chewables for Dogs 4-10 lbs	11.3 mg Afoxolaner	3 Chews	US$61.00
NexGard Chewables for Dogs 10.1-24 lbs	28.3 mg Afoxolaner	3 Chews	US$65.00
NexGard Chewables for Dogs 24.1-60 lbs	68 mg Afoxolaner	3 Chews	US$59.00

Can Nexgard or Advantage Multi cause allergic reactions?

Both NexGard and Advantage Multi can potentially cause allergic reactions in dogs.

NexGard:

• Allergic reactions may include symptoms such as hives, facial swelling, and skin irritation. Other side effects can involve gastrointestinal upset and neurological symptoms like muscle tremors or seizures, particularly in dogs with a history of seizures.

Advantage Multi:

• This medication can also lead to allergic reactions, including hives, swelling, and other symptoms like vomiting, diarrhea, and lethargy. In some cases, severe reactions may occur, necessitating immediate veterinary attention.

If you suspect an allergic reaction, consult your veterinarian promptly.

Are there any drug interactions with Nexgard or Advantage Multi?

NexGard and Advantage Multi have different profiles regarding drug interactions.

NexGard: According to studies, NexGard (afoxolaner) can be used safely with various medications, including vaccines, antibiotics, steroids, NSAIDs, and antihistamines, without adverse reactions reported.

Advantage Multi: The imidacloprid component has no known drug interactions. However, the moxidectin component may interact with several medications, including:

• Alpha/beta blockers (e.g., carvedilol)
• Antiarrhythmics (e.g., amiodarone)
• Antibiotics (e.g., clarithromycin)
• Antifungals (e.g., itraconazole)
• Calcium-channel blockers (e.g., diltiazem)
• Diuretics (e.g., spironolactone)
• Immunosuppressants (e.g., cyclosporine)

Always consult a veterinarian before combining medications to ensure safety.

What’s the shelf life of Nexgard compared to Advantage Multi?

The shelf life of NexGard is typically 30 months (2.5 years) from the date of manufacture when stored properly. In comparison, Advantage Multi does not have a specified shelf life mentioned in the sources, but it is generally recommended to check the expiration date printed on the package and not use it past that date.

Thus, NexGard has a longer shelf life than Advantage Multi, which relies on individual expiration dates.

Where can I buy Nexgard?

At Anipetshop, you can buy NexGard without a vet prescription. Anipetshop is an online retailer that specializes in pet medications, including flea and tick treatments. We offer a variety of products for dogs and cats, sourced from reputable manufacturers. Their platform allows you to purchase products conveniently, without the need for a prescription, making it easier to access essential pet medications. NexGard is available in different dosages to suit the size of your dog