Nexgard vs Frontline Plus Comparison
Nexgard vs Frontline Plus: Similarities
Nexgard and Frontline Plus are both effective flea and tick treatments for dogs, designed to protect pets from parasitic infestations. Both treatments work for an entire month, providing ongoing protection against fleas and ticks when administered regularly. They are suitable for use in puppies from 8 weeks of age.
Both Nexgard and Frontline Plus are designed to kill fleas and ticks, making them popular among pet owners for their reliability. Additionally, both products provide waterproof protection, ensuring that they remain effective even if your dog gets wet due to swimming or bathing.
These treatments are safe for long-term use in dogs, allowing for year-round protection against fleas and ticks. Their regular use helps prevent infestations and protect pets from flea and tick-borne diseases.
What Are the Differences Between Nexgard and Frontline Plus?
When comparing Nexgard and Frontline Plus, the most noticeable difference is their method of administration. Nexgard is an oral treatment, offered as a beef-flavored chewable tablet, making it easy to give to dogs that enjoy treats. In contrast, Frontline Plus is a topical solution applied directly to the dog’s skin between the shoulder blades, which requires a more hands-on approach.
In terms of speed, Nexgard works faster, killing fleas within 4 hours and ticks within 24 hours, offering rapid relief for your pet. Frontline Plus takes slightly longer, eliminating fleas within 12 hours and ticks within 48 hours. Additionally, Frontline Plus also kills chewing lice and prevents flea re-infestation by targeting flea eggs and larvae, offering broader parasite coverage.
The ingredients in both treatments also differ. Nexgard uses afoxolaner, which disrupts the GABA channels in fleas and ticks, resulting in their death. Frontline Plus contains two active ingredients: Fipronil, which attacks the parasites’ nervous system, and (S)-Methoprene, an insect growth regulator that prevents the growth of flea eggs and larvae.
Another distinction is their suitability for different life stages of dogs. Nexgard is FDA-approved for treating flea and tick infestations but has not been evaluated for use in breeding, pregnant, or lactating dogs. On the other hand, Frontline Plus is safe for use on breeding, pregnant, and lactating dogs, making it a better option for dogs in these conditions.
When considering broader protection, Frontline Plus covers all life stages of fleas and lice, whereas Nexgard focuses on killing adult fleas and ticks and is particularly effective against black-legged ticks, which can transmit Lyme disease.
In summary, Both Nexgard and Frontline Plus provide effective month-long protection against fleas and ticks, but their differences in administration, speed of action, and parasite coverage might help guide your decision. If you prefer a quick, oral treatment with fast flea and tick elimination, Nexgard is a solid option. However, if your dog needs broader protection against flea eggs, larvae, lice, and you’re looking for a product safe for breeding or pregnant dogs, Frontline Plus is the better choice.
Always consult with your veterinarian to determine the most appropriate treatment based on your dog’s health and lifestyle.
The table below provides a side-by-side comparison of Nexgard and Frontline Plus, outlining their key benefits and differences. By examining these features, you can confidently select the product that best meets your dog’s unique needs.
| Feature | Frontline Plus | NexGard |
| Kills Fleas | Yes | Yes |
| Repels Fleas | No | No |
| Kills Flea Eggs and Larvae | Yes | Kills fleas before they can lay eggs |
| Kills Ticks | Yes | Yes |
| Repels Ticks | No | No |
| Repels Mosquitoes | No | No |
| Prevents Heartworm | No | No |
| Protects Against Other Parasites | Treats Lice | No |
| Waterproof | Yes | Yes – taken orally |
| How Long to Work | Kills fleas within 24 hours; ticks and lice within 48 hours | Kills fleas within 4 hours; ticks within 24 hours |
| Taste | N/A | Beef flavored |
| Active Ingredient | Fipronil and (S)-Methoprene | Afoxolaner |
| Application Type | Topical | Chewable Tablet |
| Dosing | 1 application per month | 1 tablet per month |
| Age | Dogs 8 weeks and older | Puppies 8 weeks and older, weighing more than 4 lbs |
| Manufacturer | Boehringer Ingelheim | Boehringer Ingelheim |
| Safety | Breeding, pregnant, and lactating dogs may use | Not yet evaluated for use in breeding, pregnant, or lactating dogs |
| Side Effects | Redness, irritation, or hair loss, Drooling, Nausea, Vomiting, though rarely | Vomiting, diarrhea, lethargy, rare neurological effects |
| Duration of Effectiveness | 30 days | 35 days |
| Price | Moderate per dose | Moderate per dose |
| Clinical Studies | Demonstrated high effectiveness in clinical trials | Demonstrated high effectiveness in clinical trials |
| Storage Instructions | Store at room temperature below 30°C (86°F) | Store at room temperature 30°C (86°F) with excursions permitted up to 40°C (104°F). |
To help pet owners make an informed choice, the following table provides pricing details for Nexgard, including different dosages and quantities available at Anipetshop. This breakdown allows you to find the most cost-effective solution for your dog’s parasitic prevention needs.
| Product | Dosage | Package Size | Price |
| NexGard Chewables for Dogs 4-10 lbs | 11.3 mg Afoxolaner | 3 Chews | US$61.00 |
| NexGard Chewables for Dogs 10.1-24 lbs | 28.3 mg Afoxolaner | 3 Chews | US$65.00 |
| NexGard Chewables for Dogs 24.1-60 lbs | 68 mg Afoxolaner | 3 Chews | US$59.00 |
Can pregnant or nursing dogs use Nexgard or Frontline Plus?
Both products are safe for dogs when used as directed, and Nexgard is FDA-approved for treating and preventing flea and tick infestations. However, unlike Frontline Plus, Nexgard has not yet been tested for safety in breeding, pregnant, or nursing dogs.
Is NexGard or Frontline Plus better?
Both Frontline Plus and Nexgard are safe and reliable options for treating fleas and preventing flea-related issues like flea allergy dermatitis. They are equally effective in protecting dogs from flea infestations. However, Nexgard provides better control when it comes to ticks.
Are Nexgard and Frontline Plus safe for all dog breeds?
NexGard and Frontline Plus are generally safe for all dog breeds. NexGard is approved for dogs 8 weeks and older, weighing at least 4 pounds, and is safe for breeds with the MDR1 gene mutation. However, caution is advised for dogs with a history of seizures. Frontline Plus is also suitable for dogs over 8 weeks and effective against fleas and ticks. Always consult your veterinarian to ensure the safety and appropriateness of these treatments for your specific dog’s breed and health status.
Where can I buy Nexgard?
At Anipetshop, you can buy NexGard without a vet prescription. Anipetshop is an online retailer that specializes in pet medications, including flea and tick treatments. We offer a variety of products for dogs and cats, sourced from reputable manufacturers. Their platform allows you to purchase products conveniently, without the need for a prescription, making it easier to access essential pet medications. NexGard is available in different dosages to suit the size of your dog.
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Lily Watson is an author specializing in veterinary care in Australia. With a profound passion for animal welfare and a solid foundation in veterinary science, Lily has dedicated herself to disseminating valuable knowledge and information for both pet owners and professionals in this field.