Simparica vs Credelio vs Simparica Trio

When it comes to protecting your dog from common parasites like fleas, ticks, and other threats, choosing the right treatment is crucial. Three popular options in the market are Simparica, Credelio, and Simparica Trio. Each of these products offers effective solutions to safeguard your dog, but they differ in terms of the parasites they target, the active ingredients they contain, and the additional benefits they provide. In this comparison, we’ll explore the key features, effectiveness, and safety profiles of Simparica, Credelio, and Simparica Trio, helping you make an informed decision on which treatment is best suited for your dog’s needs.

What are the key differences between Simparica, Credelio and Simparica Trio?

When choosing the right flea and tick treatment for your dog, it’s important to understand both the similarities and differences between available options. Simparica, Credelio, and Simparica Trio are all once-monthly, chewable tablets that effectively kill fleas and ticks. They are not considered safe for use in lactating, pregnant, or breeding dogs.

However, there are key differences among these treatments that should be considered before making your decision. Firstly, each medication contains a different active ingredient: Simparica uses Sarolaner, which kills fleas within 3 hours and ticks within 8 hours, while Credelio uses Lotilaner, which kills fleas within 12 hours and ticks within 8 hours. Simparica Trio, on the other hand, combines Sarolaner with Moxidectin and Pyrantel, making it effective not only against fleas and ticks but also for preventing heartworm disease and treating roundworms and hookworms.

In terms of usage for young dogs, Credelio is formulated for puppies weighing at least 4.4 pounds and 8 weeks old, while Simparica is safe for puppies weighing at least 2.8 pounds and 6 months old. Simparica Trio is similar to Simparica in that it is also suitable for puppies weighing at least 2.8 pounds but can be used from 8 weeks of age.

The table below presents a side-by-side comparison of these treatments, making it easy to evaluate the benefits and key differences of each option. By examining these features, you can confidently choose the product that best meets your dog’s specific needs.

Feature	Simparica	Credelio	Simparica Trio
Kills Fleas	Yes	Yes	Yes
Kills Ticks	Yes	Yes	Yes
Kills Flea Eggs and Larvae	No	No	No
Repels Fleas	No	No	No
Repels Ticks	No	No	No
Prevents Heartworm	No	No	Yes
Other Parasites	No	No	Yes (Roundworms, Hookworms)
Repels Mosquitoes	No	No	No
How Long to Work	Kills fleas within 3 hours and ticks within 8 hours	Kills 100% of fleas in 12 hours and 98.7% of ticks in 8 hours	Kills fleas within 4 hours and ticks within 8 hours
Taste	Liver	Beef Flavored	Pork-liver flavor
Waterproof	Yes, since taken orally	Yes, since taken orally	Yes, since taken orally
Active Ingredient	Sarolaner	Lotilaner	Sarolaner, Moxidectin, Pyrantel
Side Effects	Vomiting, diarrhea, lethargy, anorexia, seizures in some cases	Vomiting, diarrhea, lethargy, anorexia, weight loss in some cases	Vomiting, diarrhea, lethargy, anorexia, seizures in some cases
Dosing	1 tablet per month	1 tablet per month	1 tablet per month
Application Type	Chewable Tablet	Chewable Tablet	Chewable Tablet
Age	Dogs 6 months and older weighing at least 2.8 pounds	Dogs 8 weeks and older that weigh at least 4.4 pounds	Dogs 8 weeks and older weighing at least 2.8 pounds
Manufacturer	Zoetis	Elanco	Zoetis
Safety	The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.	The safe use of Credelio in breeding, pregnant or lactating dogs hasn’t been evaluated.	The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs
Duration of Effectiveness	30 days	30 days	30 days
Price	Generally higher per dose compared to similar products	Generally moderate per dose compared to similar products	Generally higher per dose compared to similar products
Clinical Studies	Demonstrated high effectiveness in clinical trials	Demonstrated high effectiveness in clinical trials	Demonstrated high effectiveness in clinical trials
Storage Instructions	Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).	Store at 15-25°C (59 -77°F), excursions permitted between 5 to 40°C (41 to 104°F).	Store at or below 30°C (86°F)

Lastly, there are cost differences to consider. Credelio is typically slightly more expensive than Simparica, while Simparica Trio, due to its broader spectrum of protection, is generally priced higher than both Simparica and Credelio. Each option has its strengths, so choosing the right one depends on your dog’s specific needs.

The following table provides a comprehensive overview of the pricing for Simparica, Credelio, and Simparica Trio products available at Anipetshop. Each product is offered in various dosages and quantities, allowing you to choose the best option for your dog’s needs. Prices range based on the specific product variant and the number of tablets per package, helping you find the most cost-effective solution for flea, tick, and parasite protection.

Product	Price (USD)
Credelio
Credelio for Dogs 2.86-5.51 lbs	$63.00
Credelio for Dogs 6.1-12 lbs	$63.00
Credelio for Dogs 12.1-25 lbs	$64.00
Credelio for Dogs 25.1-50 lbs	$66.00
Credelio for Dogs 50.1-100 lbs	$69.00
Simparica
Simparica for Dogs 2.8-5.5 lbs	$46.00 – $90.00
Simparica for Dogs 5.6-11 lbs	$47.00 – $92.00
Simparica for Dogs 11.1-22 lbs	$50.00 – $95.00
Simparica for Dogs 22.1-44 lbs	$51.00 – $99.00
Simparica for Dogs 44.1-88 lbs	$53.00 – $103.00
Simparica for Dogs 88.1-132 lbs	$56.00 – $108.00
Simparica Trio
Simparica Trio for Dogs 2.8-5.5 lbs	$65.00 – $126.00
Simparica Trio for Dogs 5.6-11 lbs	$60.00 – $128.00
Simparica Trio for Dogs 11.1-22 lbs	$75.00 – $230.00
Simparica Trio for Dogs 22.1-44 lbs	$77.00 – $230.00
Simparica Trio for Dogs 44.1-88 lbs	$79.00 – $230.00
Simparica Trio for Dogs 88.1-132 lbs	$81.00 – $230.00

When considering age and weight, Credelio is formulated for puppies as young as 8 weeks, making it a great option for early flea and tick protection, especially in smaller breeds. It is suitable for dogs weighing at least 4.4 lbs. Simparica and Simparica Trio, on the other hand, are recommended for dogs over 6 months old. Simparica Trio has the added benefit of being safe for younger puppies (starting at 8 weeks) as long as they weigh at least 2.8 lbs, making it a flexible option across different life stages.

Parasite Coverage

If you’re looking for comprehensive protection, Simparica Trio stands out by covering fleas, ticks, heartworms, roundworms, and hookworms. This broad-spectrum coverage is ideal for dogs in areas where multiple parasites are a concern. Simparica and Credelio both effectively target fleas and ticks but do not offer protection against heartworms or intestinal parasites, which might require additional treatments.

Active Ingredients

Simparica uses Sarolaner, a fast-acting ingredient highly effective against fleas and ticks. It’s ideal if your dog needs rapid relief and has previously tolerated Sarolaner well. On the other hand, Credelio contains Lotilaner, which also offers strong flea and tick control but with a different mechanism of action. Credelio is a good alternative if your dog is sensitive to other treatments like Sarolaner. Simparica Trio combines Sarolaner with Moxidectin and Pyrantel, making it suitable for dogs needing broader protection, including heartworms and intestinal worms. Understanding how your dog responds to these ingredients helps in making the best choice.

Speed of Action

When considering the speed of action, Simparica is the best choice for immediate relief, killing fleas within 3 hours and ticks within 8 hours. This makes it ideal for dogs that need rapid elimination of existing infestations. Simparica Trio, while slightly slower, begins killing fleas within 4 hours and achieves 100% effectiveness in 8 hours, making it a strong option when broader parasite protection is also required. Credelio offers reliable flea control, starting in 4 hours and maintaining 99% effectiveness over 35 days, suitable for long-term flea management. It’s particularly suitable for dogs that may need a gentler approach or when a slower onset of action is acceptable.

Side Effects

All three treatments have similar potential side effects, including vomiting, diarrhea, and lethargy. Simparica and Simparica Trio have also been associated with rare cases of seizures, which is something to consider, especially if your dog has a history of neurological issues. Credelio might have a slightly different side effect profile due to its different active ingredient. Discussing these possibilities with your vet can help minimize risks.

Price

Cost can be a significant factor in your decision. Simparica Trio generally has a higher price point due to its additional coverage for heartworms and intestinal parasites. Simparica is slightly more affordable, offering strong flea and tick protection. Credelio falls in between, often being moderately priced but without the broader spectrum of protection offered by Simparica Trio. Balancing your budget with your dog’s specific needs will help you choose the most cost-effective solution.

In conclusion, Simparica is best for quick flea and tick elimination, Credelio suits younger puppies needing consistent protection, and Simparica Trio offers comprehensive coverage, including heartworms and intestinal parasites. Your choice should align with your dog’s specific needs, life stage, and any existing health conditions, with guidance from your veterinarian.