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Bravecto Chews For Dogs 88-123 Lbs (40-56 Kg)
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Description
Bravecto Chews For Dogs 88-123 Lbs (40-56 Kg) contains 1400 mg fluralaner per chew, the highest single-dose concentration in the Bravecto Chews range, calibrated to deliver a minimum of 11.4 mg/lb (25 mg/kg) body weight for dogs in this weight category. As an isoxazoline-class compound, fluralaner acts systemically by blocking GABA-gated and glutamate-gated chloride channels in the arthropod nervous system, killing parasites through blood contact rather than requiring prior surface exposure. One chew covers 12 weeks of flea and tick protection for four tick species, with lone star tick (Amblyomma americanum) coverage extending to 8 weeks. Dogs exceeding 123 lbs (56 kg) should receive the appropriate combination of chews to meet the minimum labeled dose; consult a veterinarian to confirm the correct combination before dosing.
Recommended for:
Dogs and puppies weighing 88–123 lbs (40–56 kg), aged 6 months and older.
Indication/Coverage:
For dogs suffering from, or at risk from, flea and tick infestations, Bravecto Chews 88–123 lbs addresses the following parasites and conditions:
- Flea treatment and prevention: Kills adult cat fleas (Ctenocephalides felis) and dog fleas (Ctenocephalides canis) within 8 hours of attachment, with sustained lethal activity throughout the full 12-week dosing interval.
- Black-legged tick (deer tick) control: Treatment and control of Ixodes scapularis infestations for 12 weeks; this species is the predominant vector of Lyme disease across the northeastern and upper midwestern United States.
- American dog tick control: Treatment and control of Dermacentor variabilis for 12 weeks; a confirmed vector of Rocky Mountain spotted fever distributed broadly across the continental U.S.
- Brown dog tick control: Treatment and control of Rhipicephalus sanguineus for 12 weeks, with adult-stage efficacy confirmed at 48 hours post-infestation in controlled laboratory studies.
- Asian longhorned tick control: Treatment and control of Haemaphysalis longicornis for 12 weeks; an invasive species established across multiple U.S. states, with documented efficacy at 48 hours post-infestation.
- Lone star tick control: Treatment and control of Amblyomma americanum for 8 weeks in dogs 6 months of age and older; fluralaner does not sustain 90% or greater efficacy against this species beyond week 8, and this indication does not extend to puppies under 6 months.
- Flea Allergy Dermatitis (FAD) management: Sustained elimination of flea populations removes the antigenic trigger driving allergic responses in sensitized dogs, supporting FAD management protocols where flea source control is the primary clinical objective.
- Environmental flea cycle disruption: Newly emerged fleas feeding on a treated dog are killed before producing viable eggs, interrupting the reinfestation cycle in areas the dog regularly occupies.
- Reduction of tapeworm and tick-borne disease risk: Controlling flea and tick populations eliminates the intermediate hosts and vectors transmitting Dipylidium caninum (tapeworm) and tick-borne pathogens including Borrelia burgdorferi and Rickettsia rickettsii.
Key Benefits:
The following characteristics are drawn directly from the FDA-approved label for Bravecto Chews (fluralaner) 1400 mg.
- Giant and large breed coverage: Labeled for dogs from 88 lbs (40 kg) through 123 lbs (56 kg), covering breeds such as Great Danes, Saint Bernards, Rottweilers, and large Mastiff-type dogs at typical adult weight.
- Single chew, five tick species: One 1400 mg chew addresses five distinct tick species per dose, encompassing the vectors of Lyme disease, Rocky Mountain spotted fever, and the invasive Asian longhorned tick without requiring additional ectoparasite products.
- Bloodstream delivery, coat-independent efficacy: Fluralaner circulates systemically and reaches parasites at the point of feeding; neither coat density, bathing frequency, nor water exposure after dosing diminishes efficacy, unlike topical formulations reliant on skin surface residue.
- Flea kill within 8 hours: Adult fleas are eliminated within 8 hours of attachment at the labeled dose, curtailing allergen transfer and egg deposition before the parasite dies and thereby limiting reinfestation pressure from treated dogs.
- Quarterly dosing interval: Four administrations per year maintain continuous flea and tick coverage for four species, substantially reducing the dosing burden compared to twelve annual doses required by monthly oral parasiticides.
- Oral format eliminates topical application challenges: Administering a single flavored chew removes the practical difficulty of parting a dense double coat on a large-breed dog to reach bare skin at the interscapular application site, a common barrier to consistent topical compliance.
- Field-confirmed FAD lesion resolution:S. field study data document measurable improvement in erythema, alopecia, papules, scales, crusts, and excoriation in dogs presenting with flea allergy dermatitis, following sustained flea population elimination by fluralaner.
- Labeled food requirement for absorption: Fluralaner bioavailability is documented to be lower in the fasted state; the product label specifies administration with food as a requirement for this formulation, not a general recommendation.
Caution:
Hazards to Humans
Bravecto Chews are not for human use. Keep the product in its original blister packaging and out of children’s reach until the moment of administration. Avoid eating, drinking, or smoking while handling. Wash hands with soap and water immediately after giving the dose to the dog.
Hazards to Domestic Animals
Bravecto Chews are for oral administration only. The 88–123 lb variant is labeled exclusively for dogs and puppies that have attained at least 88 lbs (40 kg) in body weight and are aged 6 months or older; animals below either threshold should not receive this tablet. Consult a veterinarian before use in debilitated, aged, pregnant, or lactating animals. Fluralaner belongs to the isoxazoline class, which carries a labeled precaution for neurologic adverse reactions including tremors, ataxia, and seizures; these have been reported in dogs with no prior seizure history. Exercise particular caution in dogs with known seizure or neurological disorders, and review post-approval experience data before use in breeding females. Verify all concurrent medications with a veterinarian prior to the first dose.
Possible Side Effects:
Monitor your dog carefully in the hours following administration of Bravecto Chews, with heightened vigilance after the first dose in the 88–123 lb range.
The adverse reactions below were documented in the controlled U.S. field study (182-day observation period, n=224 dogs) and in post-approval adverse drug experience reports submitted to the FDA/CVM:
- Vomiting: Reported in 7.1% of Bravecto-group dogs; the most frequently recorded GI sign in the field study, typically self-limiting and resolving without medical intervention.
- Decreased appetite: Reported in 6.7% of treated dogs and absent in the active control group, indicating a product-associated occurrence rather than a background rate.
- Lethargy: Reported in 5.4% of field study dogs; the majority of cases resolved during the observation period without requiring treatment.
- Diarrhea: Reported in 4.9% of dogs; post-approval FDA/CVM reports include bloody diarrhea in a subset of affected animals.
- Polydipsia: Reported in 1.8% of Bravecto-group dogs across the 182-day study period.
- Flatulence: Reported in 1.3% of dogs in the treated group.
- Neurologic signs: Post-approval reports to the FDA/CVM include tremors, ataxia, and seizures in dogs receiving isoxazoline-class drugs, including animals with no documented prior seizure history.
- Dermal and allergic reactions: Post-approval surveillance captures pruritus, hives, erythema, swelling, and dermatitis presenting as crusts, pustules, or rash.
If any of these signs develop after administration, contact your veterinarian for advice and evaluation. The dog should be examined before the next scheduled dose if any neurologic or allergic signs have occurred.
Direction
Administer Bravecto Chews For Dogs 88-123 Lbs (40-56 Kg) orally as a single dose every 12 weeks. The chew must be given with or immediately after a meal, as fluralaner absorption is measurably reduced in the fasted state; this is a labeled requirement, not a general suggestion. In multi-dog households, separate animals during and after dosing: a 1400 mg chew calibrated for a 100 lb dog poses a significant overdose risk if consumed by a smaller animal. Store unused blister packs in a secured location inaccessible to all pets.How to Open:
- Remove the product carton and extract the aluminum foil blister pack from inside.
- If the pack is part of a multi-unit perforated sheet, separate the required blister unit by tearing along the scored perforation line.
- Identify the corner tab on the paper-backed foil lid and peel it back in a single controlled motion until the blister cup is fully exposed.
- Press upward from beneath the base of the blister cup to release the chew cleanly without crushing or fragmenting it.
How to Administer:
- Weigh the dog on the day of dosing to confirm current body weight falls within 88–123 lbs (40–56 kg); do not substitute a figure from a prior veterinary visit.
- Remove the 1400 mg fluralaner chew from the opened blister unit.
- Present the chew by hand alongside or after the dog's regular meal; in the U.S. field study, 80.7% of dogs voluntarily accepted the dose within 5 minutes.
- If the dog declines the chew independently, embed it in or alongside a small portion of food; 12.5% of field study dogs accepted the dose via this approach.
- For dogs that refuse both methods, place the chew at the base of the tongue, hold the muzzle closed, and confirm swallowing before releasing. Record the dosing date and schedule the next administration exactly 12 weeks later.
Storage:
Store Bravecto Chews below 30°C (86°F). Retain each chew in its original aluminum foil blister packaging until the point of use; premature removal from the packaging confers no benefit and unnecessarily exposes the product. Verify the expiry date printed on the outer carton before each dose; the stated date refers to the last day of the printed month. Keep the product out of reach of children and all household animals at all times.Tips for Using:
The following guidance applies specifically to administering Bravecto Chews to dogs in the 88–123 lb range:- Food is non-negotiable at this dose: Fluralaner bioavailability is lower in a fasted dog, and at 1400 mg per chew this is the highest-concentration variant in the Bravecto Chews range. Administering without food risks a subtherapeutic plasma concentration that may not sustain the full 12-week efficacy window.
- Mark the 12-week date immediately after dosing: The quarterly interval does not align with a calendar month, making unintentional gaps more common than with monthly products. Setting a fixed recurring reminder on the administration date prevents coverage lapses that arise from estimating the interval retrospectively.
- Reweigh large breeds before each dose: Body weight in giant-breed dogs can fluctuate significantly with seasonal activity, health status, or dietary changes. Dogs approaching or below 88 lbs on a given dose date should be confirmed against the lower boundary before administering the 1400 mg chew; those below 88 lbs should receive the 44–88 lb variant instead.
- For dogs over 123 lbs, combine chews as directed: The product label specifies that dogs exceeding 123 lbs should receive the appropriate combination of chews to meet the minimum labeled dose of 11.4 mg/lb (25 mg/kg). Do not substitute a single 1400 mg chew for a dog above this threshold; consult a veterinarian to determine the correct combination before dosing.
- Watch for GI signs in the first two hours: Vomiting and decreased appetite occurred at higher rates in the Bravecto treatment group than in the active control in the U.S. field study. Observe the dog for at least 1 to 2 hours after the first administration;If vomiting occurs within 30 minutes, contact your veterinarian before the next scheduled dose.
- Secure the 1400 mg chew away from all other animals: At this concentration, accidental ingestion by a smaller dog, a cat, or a puppy constitutes a serious overdose. Store blister packs in a latched cabinet or elevated location no other household animal can access, both before opening and during the brief window between removing the chew from storage and presenting it to the dog.
| Product Name | Bravecto Chews for Dogs 88-123 lbs (40-56 kg) |
|---|---|
| Target Weight | 88 – 123 lbs (40 – 56 kg) |
| Packaging Color | Pink |
| Active Ingredients | Fluralaner: 1400 mg per chew |
| Application Type | Pork flavored chewable tablet |
| Appearance | Brown chewable tablet |
| Administration Route | Oral administration |
| Pack Sizes Available | 1 or 2 chews per package (individual aluminum foil blister packs) |
| Treatment Frequency | Once every 12 weeks for fleas and four tick species; every 8 weeks where Amblyomma americanum (lone star tick) exposure is a documented risk |
| Effective Against | – Fleas: Ctenocephalides felis, Ctenocephalides canis (adults) |
| Storage | Below 30°C (86°F); retain in original blister packaging until use |
FAQs
1. My dog weighs exactly 88 lbs. Is the 88–123 lb chew correct, or should I use the 44–88 lb variant?
The 88-123 lb chew (1400 mg fluralaner) is intended for dogs weighing more than 88 lbs. Dogs weighing exactly 88 lbs on the day of dosing should receive the 44–88 lb chew (1000 mg fluralaner). Dogs weighing more than 123 lbs require a combination of chews according to the labeled dosage schedule; consult a veterinarian to determine the appropriate combination. Bravecto Chews are available in four other weight-based variants:
- Bravecto Chews For Dogs 4.4-9.9 Lbs (2-4.5 Kg)
- Bravecto Chews For Dogs 9.9-22 Lbs (4.5-10 Kg)
- Bravecto Chews For Dogs 22-44 Lbs (10-20 Kg)
- Bravecto Chews For Dogs 44-88 Lbs (20-40 Kg)
2. Is 1400 mg of fluralaner safe for a dog at the lower end of this range, around 89–95 lbs?
Yes. The 1400 mg dose is calibrated to deliver a minimum of 11.4 mg/lb (25 mg/kg) across the full >88–123 lb range, including dogs at 89 lbs. In the FDA margin of safety study, dogs received fluralaner at 1×, 3×, and 5× the maximum label dose without clinically relevant adverse findings on organ pathology, hematology, or body weight. Dogs with a history of seizures or neurological conditions require individual veterinary assessment before the first dose, as the isoxazoline class carries a specific labeled precaution for this group.
3. My dog just crossed from 87 lbs into this range. Do I switch to the 1400 mg chew immediately at the next dose?
Switch at the next scheduled dose date once the dog’s confirmed weight exceeds 88 lbs on the day of dosing. Do not administer the higher-dose chew mid-interval if the previous 1000 mg dose was given within the preceding 12 weeks. Body weight in large breeds can shift between veterinary visits; weigh on the actual dosing day rather than relying on a previously recorded figure.
4. I missed the 12-week window by 3 weeks. What should I do now?
Administer the dose as soon as the gap is recognized and reset the 12-week schedule from that new date. Do not give a double dose to compensate. The three-week lapse represents a period without active flea and tick coverage; if the dog was in a tick-endemic area during that window, examine the coat and skin before redosing and seek veterinary advice if any ticks were found attached.
5. My dog weighs 130 lbs. Can I give two chews from this range?
The product label states that dogs over 123 lbs should receive the appropriate combination of chews to meet the minimum labeled dose of 11.4 mg/lb (25 mg/kg). For a 130 lb dog, a single 1400 mg chew delivers approximately 10.8 mg/lb, which falls below the minimum labeled dose. Consult a veterinarian to confirm the correct chew combination before dosing; self-selecting a combination without veterinary input risks underdosing in a dog of this size.
6. My 100 lb Rottweiler has epilepsy managed with phenobarbital. Can I still use Bravecto Chews?
Do not administer without explicit veterinary clearance. Fluralaner is an isoxazoline-class drug with a labeled precaution for dogs with a history of seizures or neurological disorders, and seizures have been reported even in dogs with no prior seizure history. A dog already on antiepileptic medication represents a heightened risk profile for neurologic adverse reactions. The veterinarian managing the dog’s epilepsy should assess whether fluralaner is appropriate before any dose is given.
7. Does the 88–123 lb Bravecto Chew protect against lone star ticks for 12 weeks?
No. Lone star tick (Amblyomma americanum) protection is labeled at 8 weeks for this variant. Laboratory data confirm efficacy at or above 90% through week 8 post-dosing, but that threshold is not maintained beyond that point. Dogs in regions with significant lone star tick pressure, particularly across the southeastern and south-central United States, should be dosed on an 8-week interval to maintain coverage against this species specifically.
8. My 95 lb dog vomited about 15 minutes after eating the 1400 mg chew. Has the dose been absorbed?
Fluralaner reaches peak plasma concentration between 2 hours and 3 days post-ingestion. Vomiting at 15 minutes raises a substantive concern that little to none of the dose was absorbed. Do not automatically redose; Consult a veterinarian to determine whether a repeat administration is warranted based on the timing and the volume of material retrieved.
9. Can my 110 lb dog swim the day after receiving the Bravecto Chew?
Yes, without restriction. Fluralaner is a systemic oral medication distributed through the bloodstream, not deposited on the skin or coat surface. Swimming, bathing, or water exposure at any point after oral administration has no effect on the drug’s plasma concentration or its efficacy. This is a clinically relevant distinction from topical spot-on products, where post-application water contact within a defined window can reduce surface drug levels and compromise coverage.
10. My 105 lb Great Dane is pregnant. Is the 88–123 lb Bravecto Chew safe to use?
Post-approval adverse event reports include birth defects in pups from dams treated with fluralaner in the reproductive safety study, with abnormalities observed in 7 pups from 2 of 10 treated dams. Use in pregnant dogs is not explicitly contraindicated on the label, but the product insert directs veterinary review of the post-approval experience and animal safety data before use in breeding females. Consult a veterinarian before administering fluralaner to a pregnant or lactating dog of any weight.
13 reviews for Bravecto Chews For Dogs 88-123 Lbs (40-56 Kg)
| 5 star | 69% | |
| 4 star | 15% | |
| 3 star | 15% | |
| 2 star | 0% | |
| 1 star | 0% |
1-5 of 13 reviews
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After trying several flea preventatives, we’ve finally found one that works consistently. No more flea outbreaks or constant vacuuming for us.
I love how Bravecto provides months of protection with just one dose.
I was skeptical about switching from topical treatments, but these chews have won me over. My dog thinks he’s getting a treat, and I know he’s protected.
We love this chewable tablet. It’s effective, easy to administer, and our dog’s health has never been better.
It’s a relief to know our dog is protected from parasites. This product is easy to give and works very well.