Heartgard vs Heartgard Plus

Heartworm disease is a serious and potentially fatal condition that can affect dogs. As a responsible pet owner, it’s crucial to protect your furry companion from this preventable disease. One popular choice for heartworm prevention is Heartgard, but there’s also Heartgard Plus available in the market. In this article, we’ll compare Heartgard and Heartgard Plus to help you make an informed decision about the best option for your pet’s needs.


Buy Heartgard Plus

Features Heartgard Heartgard Plus
Active Ingredients Ivermectin Ivermectin and Pyrantel Pamoate
Heartworm Protection Yes Yes
Roundworm Protection No Yes
Hookworm Protection No Yes
Whipworm Protection No No
Tapeworm Protection No No
Flea Protection No No
Tick Protection No No
Form Chewable Tablet Chewable Tablet
Administration Frequency Monthly Monthly
Suitable for Dogs Over 6 weeks of age Over 6 weeks of age
Prescription Required Yes Yes
Broad-Spectrum No Yes
Additional Parasites N/A Roundworms and Hookworms
Safety Record Proven safety record Proven safety record
Veterinary Guidance Consult with a veterinarian for more details Consult with a veterinarian for more details

Heartgard vs Heartgard Plus: Which Heartworm Preventive is Right for Your Dog?

Heartgard vs Heartgard Plus Anipetshop


Heartgard is a well-known brand of heartworm preventive that has been trusted by veterinarians and pet owners for many years. It contains ivermectin as its active ingredient, which effectively kills heartworm larvae (Dirofilaria immitis) before they can mature into adult worms. Heartgard is available in a chewable tablet form, making it convenient and easy to administer to dogs.

Key Features of Heartgard:

  • Active Ingredient: Ivermectin.
  • Prevents heartworm disease by killing heartworm larvae.
  • Administered in a chewable tablet form.
  • Requires monthly administration.
  • Suitable for dogs over six weeks of age.

Heartgard Plus:

Heartgard Plus is an upgraded version of Heartgard that offers additional protection against certain intestinal parasites. In addition to ivermectin, it contains pyrantel pamoate, which helps eliminate and control roundworms and hookworms. This makes Heartgard Plus a broad-spectrum preventive medication that addresses multiple parasitic infections.

Key Features of Heartgard Plus:

  •  Active Ingredients: Ivermectin and pyrantel pamoate.
  • Provides protection against heartworm disease, roundworms, and hookworms.
  • Administered in a chewable tablet form.
  • Requires monthly administration.
  • Suitable for dogs over six weeks of age.

Heartgard vs Heartgard Plus: Similarities

Both Heartgard and Heartgard Plus share several similarities, including:

  1. Mode of Administration: Both medications are administered orally as chewable tablets, making them easy to give to dogs.
  2. Frequency: Both require monthly administration to maintain effective protection against heartworm disease.
  3. Safety: Both medications have a proven safety record when used as directed.

Heartgard vs Heartgard Plus: Differences

While Heartgard and Heartgard Plus have similarities, there are notable differences between the two:

  1. Parasite Coverage: Heartgard Plus offers protection against heartworm disease, roundworms, and hookworms, while Heartgard focuses solely on heartworm prevention.
  2. Active Ingredients: Heartgard contains only ivermectin, while Heartgard Plus combines ivermectin with pyrantel pamoate for additional parasite control.


When deciding between Heartgard and Heartgard Plus, it’s important to consider your dog’s specific needs and your veterinarian’s recommendations. If heartworm prevention is your primary concern and your dog does not have a significant risk of intestinal parasite infection, Heartgard can be an appropriate choice. However, if you live in an area where intestinal parasites are prevalent or your dog has a history of intestinal parasite issues, Heartgard Plus may offer the added protection you need.

It is crucial to consult with your veterinarian to determine the most suitable option for your dog. They can evaluate your pet’s health, consider any existing health conditions or medication interactions, and provide personalized advice based on your dog’s specific requirements.

Remember, regardless of which option you choose, it is essential to administer the medication consistently and as directed by your veterinarian. Regular and proper use of heartworm preventives is key to keeping your dog protected from heartworm disease and other potential parasites.


Ryan Foley
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Dr. Ryan's journey in the field of veterinary medicine began with his graduation from the University of Adelaide in 2014. Armed with a solid educational foundation, he embarked on a career dedicated to the well-being and care of animals.