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Revolution Plus Topical Solution for Cats 5.6-11 lbs (2.6-5 kg)
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NO PRESCRIPTION NEEDED
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BASED IN AUSTRALIA
Tracked Delivery 7-14 Days
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Description
Revolution Plus Topical Solution for Cats 5.6-11 lbs (2.6-5 kg) is a dual-active spot-on formulation combining selamectin and sarolaner, produced by Zoetis, that addresses seven parasite categories in a single monthly application. The orange-cap pipette delivers selamectin 30 mg and sarolaner 5 mg per dose, calibrated to the 2.6–5 kg body weight range. No oral administration is involved, which makes this variant practical for cats that refuse tablet or chewable formats.
Recommended for
Cats and kittens weighing 5.6–11 lbs (2.6–5 kg) from 8 weeks of age.
Indication/Coverage
For cats suffering from, or at risk from, mixed parasitic infections, Revolution Plus 5.6–11 lbs covers the following indications:
- Flea treatment and prevention (Ctenocephalides felis, adults): Kills adult fleas on the treated cat before egg deposition occurs, reducing both on-animal infestation and environmental flea burden over time.
- Tick treatment and control (Ixodes scapularis, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, adults): Sarolaner distributes systemically and kills attached ticks across four species of clinical significance in North America.
- Heartworm prevention (Dirofilaria immitis, L3/L4 larvae and immature adults): Monthly selamectin dosing eliminates infective larvae acquired during the preceding 30 days and clears immature adult stages that developed following initial larval exposure.
- Roundworm treatment (Toxocara cati, intestinal adults): A single topical dose clears established intestinal roundworm infections; ongoing monthly administration maintains worm-free status.
- Intestinal hookworm treatment (Ancylostoma tubaeforme, intestinal adults): Selamectin eliminates hookworm infections with a single application; monthly continuation prevents reestablishment.
- Ear mite treatment (Otodectes cynotis, adults): Administered as a single dose at the base of the neck, not into the ear canal directly; monthly use controls recurrence of infestation.
- Tapeworm prevention (Dipylidium caninum): Prevention is indirect, achieved by eliminating Ctenocephalides felis vector fleas on the treated cat and thereby breaking the primary transmission route for caninum.
Key Benefits
The following properties are drawn directly from the Revolution Plus label and field safety data for the 5.6–11 lbs orange-cap variant:
- Eligible from 8 weeks: The labeled minimum age matches the 2.8–5.5 lbs variant, so kittens that graduate into this weight band during the normal growth period can continue without interruption to their preventive schedule.
- Simultaneous seven-parasite coverage: One pipette addresses fleas, four tick species, heartworm larvae, roundworm, hookworm, ear mites, and tapeworm (via flea control), eliminating the need to coordinate multiple single-target products.
- Dual-class mechanism: Selamectin disrupts neurotransmission in parasites by interfering with glutamate-gated chloride channel conductance, while sarolaner (an isoxazoline) blocks GABA- and glutamate-gated chloride channels. These complementary mechanisms provide broad-spectrum activity against both ectoparasites and endoparasites.
- Pre-oviposition flea kill: Adult fleas are eliminated on the treated cat before laying eggs, which curtails household environmental contamination and limits the flea life cycle at its source.
- Continuous heartworm barrier: Each dose covers the full 30-day interval between applications, provided the schedule is maintained without gaps exceeding one month.
- Topical delivery: Dermal absorption at the base of the neck bypasses the gastrointestinal tract entirely, which is clinically relevant for cats with documented food aversions, pill refusal, or post-oral vomiting histories.
- Water Resistance: Avoid bathing or shampooing the treated cat for 24 hours after application, as this may decrease selamectin efficacy. After absorption, the product maintains its effectiveness despite water exposure.
Caution
Hazards to Humans
Revolution Plus contains isopropyl alcohol and butylhydroxytoluene, both of which irritate skin and eyes on contact. Wash hands with soap and water after handling. Flush eyes thoroughly if accidental contact occurs. Keep children away from treated cats for 4 hours post-application and store all pipettes out of their reach.
Hazards to Domestic Animals
Revolution Plus 5.6–11 lbs is for external use on cats only; do not apply to dogs or other species. This variant is labeled for cats weighing 5.6–11 lbs (2.6–5 kg) from 8 weeks of age. Safety in breeding, pregnant, or lactating cats has not been established in published studies; veterinary assessment is warranted before initiating treatment in these animals. Sarolaner is an isoxazoline-class compound, a drug class linked to neurologic adverse reactions including tremors, ataxia, and seizures, reported even in cats without a prior neurologic history; evaluate individual risk before the first dose.
Possible Side Effects:
Monitor your cat closely during the 2 hours following application and for the remainder of the treatment day.
- Application site reactions (selamectin, topical): Transient stiff hair, fur clumping, discoloration, or a light powdery residue at the base of the neck may appear after the product dries. These effects are self-limiting and carry no impact on the dose’s systemic efficacy.
- Dermal irritation (sarolaner, topical): Localized pruritus, erythema, or skin sensitivity at or near the application site has been reported. Signs typically resolve without treatment within 24 to 48 hours.
- Gastrointestinal signs: Hypersalivation or vomiting may follow if the cat accesses and grooms the application site before the product has dried. Do not allow the cat to lick the application site until the treatment has fully dried.
- Neurologic signs (isoxazoline class): Tremors, incoordination, or seizure activity are potential adverse effects of sarolaner in susceptible cats, including those with no prior history of neurologic disorders. Discontinue use immediately and seek veterinary attention if any of these signs emerge.
If adverse reactions are observed or worsen after the first application, consult a veterinarian.
Direction
Revolution Plus Topical Solution for Cats 5.6-11 lbs (2.6-5 kg) is applied as a spot-on topical solution at the skin surface at the base of the neck, directly in front of the shoulder blades. The fur must be parted until bare skin is fully visible before the tube contents are expressed; applying onto coat rather than skin reduces dermal absorption. Ensure your cat does not lick or groom the application site until the product is completely dry. To avoid accidental ingestion, keep treated cats away from other household pets until the treated area has dried fully.How to Open
- Remove a single pipette from the packaging by separating it along the perforated edge.
- Hold the tube upright with the cap directed away from the eyes and face.
- Press the cap firmly onto the tube tip until a distinct click is heard, confirming the internal seal has been punctured.
- Remove the cap and inspect the tip to verify it is fully open before proceeding.
How to Administer
- Part the fur at the base of the neck, in front of the shoulder blades, until the skin surface is exposed.
- Position the open tip of the pipette directly against the bare skin.
- Squeeze the tube 3 to 4 times, depositing the full contents onto a single skin spot. Do not distribute across multiple sites.
- Draw the emptied tube back across the skin as you lift it to avoid drawing liquid back into the pipette.
- Confirm the tube is fully empty before discarding; an incomplete dose reduces efficacy against all labeled parasites, particularly heartworm larvae and ticks.
Storage
Store out of reach of children. Keep below 30°C (86°F). Do not use a pipette after the expiry date printed on the outer carton; the expiry date refers to the final day of the stated month. Protect from direct heat and open flame, as the formulation is flammable.Tips for Using
To maximize the effectiveness of Revolution Plus Topical Solution for Cats (5.6–11 lbs / orange box), follow these application and management tips:- Apply directly to the skin: Separate the fur at the back of your cat’s neck, near the base of the skull, until the skin is clearly visible. Apply the product directly onto the skin, not onto the fur.
- Use a single application site: Position the tip of the tube against the exposed skin and squeeze firmly 3–4 times in the same location until the entire contents have been dispensed.
- Do not rub in the solution: Allow the treatment to absorb on its own. Avoid massaging the area or spreading the liquid by hand.
- Maintain pressure when removing the tube: Continue squeezing the tube as you lift it away from the skin to prevent any product from flowing back inside.
- Do not apply to damaged areas: Avoid using the product on cuts, abrasions, open wounds, or irritated skin, as the alcohol-based formula may cause discomfort or stinging.
- Apply only to dry skin and fur: Ensure your cat’s coat and skin are completely dry before administering the treatment.
- Open the tube properly: Hold the applicator upright and press the cap down firmly until it clicks, indicating that the seal has been pierced. Then remove the cap before use.
- Keep your cat dry after treatment: Do not bathe your cat or allow it to become wet for at least 24 hours following application.
- Prevent contact with other pets: Keep treated cats separated from other household animals until the application site has fully dried to reduce the risk of grooming-related ingestion.
- Use consistently every month: For continuous protection against parasites such as blacklegged ticks (Ixodes scapularis) and lone star ticks (Amblyomma americanum), apply one dose every 30 days throughout the year.
- If a dose is missed: Administer the treatment as soon as possible and establish a new 30-day schedule based on that date. Never apply two doses at the same time.
- Check your cat’s weight regularly: This Orange package is intended only for cats weighing between 5.6-11 lbs (2.6-5 kg). If your cat exceeds this weight range, switch to the appropriate product size to ensure effective protection.
| Product Name | Revolution Plus Topical Solution for Cats 5.6-11 lbs (2.6-5 kg) |
|---|---|
| Target Weight | 5.6 – 11 lbs (2.6 – 5 kg) |
| Packaging Color | Orange |
| Pipette Volume | 0.5 mL |
| Active Ingredients | Sarolaner: 5 mg/tube, Selamectin: 30 mg/tube |
| Key Excipients | Dipropylene Glycol Monomethylether, Isopropyl Alcohol, Butylhydroxytoluene (BHT) |
| Application Type | Topical spot-on solution applied directly to the skin at the base of the neck |
| Appearance | Colorless to yellow solution |
| Administration Route | For external use only (cats and kittens) |
| Pack Sizes Available | 3-pack or 6-pack pipettes |
| Treatment Frequency | Monthly (fleas, ticks, heartworm, roundworm, hookworm); single dose for ear mites with monthly maintenance |
| Effective Against | – Adult fleas (Ctenocephalides felis) |
| Storage | Below 30°C (86°F); keep away from heat sources and open flame |
FAQs
1. My cat weighs exactly 5.6 lbs today. Is the orange-cap tube the right size?
The 5.6–11 lbs tube (selamectin 30 mg / sarolaner 5 mg) is appropriate at exactly 5.6 lbs (2.6 kg). Cats that have not yet reached 5.6 lbs on the treatment day should remain on the gold-cap 2.8–5.5 lbs variant; consult a veterinarian if the cat’s weight is borderline and the correct variant is uncertain. Cats that have exceeded 11 lbs (5 kg) should move to the next weight-band variant. Revolution Plus is available in two other weight-based variants:
2. Is the sarolaner dose in the 5.6–11 lbs tube safe at the lower end of this weight range?
The 5 mg sarolaner dose delivers approximately 0.89 mg/lb at 5.6 lbs, which falls within the labeled therapeutic range. Field safety data from Zoetis included cats across this weight band without dose-dependent safety signals. Sarolaner is an isoxazoline compound; cats with any neurologic history warrant veterinary review before the first application regardless of body weight.
3. My cat just moved from the 2.8–5.5 lbs tube to this range. Do I switch immediately?
Switch on the next scheduled monthly dose once the cat’s weight is confirmed above 5.5 lbs on the treatment day. Do not overlap doses or administer both tubes to compensate for the transition. The orange-cap tube provides the full selamectin and sarolaner doses appropriate for this weight band from the first application.
4. What should I do if I miss a monthly dose of Revolution Plus 5.6–11 lbs?
Apply the missed dose as soon as it is noticed and resume the regular monthly schedule from that new date. Do not administer two doses in close succession. Cats in heartworm-endemic regions that have gone without coverage for more than 30 days should be evaluated by a veterinarian before restarting, as larvae acquired during the gap may have progressed beyond the larval stage that selamectin targets.
5. Can I use Revolution Plus on my cat if she is currently nursing kittens?
The safety of Revolution Plus in lactating cats has not been established in controlled studies. The prescribing information lists nursing as a situation requiring veterinary assessment before initiating treatment. A veterinarian should weigh the benefit of parasite prevention against the absence of lactation safety data before this variant is used.
6. My cat has had one seizure episode in the past. Is Revolution Plus 5.6–11 lbs safe to use?
Sarolaner, one of the two active compounds in Revolution Plus, belongs to the isoxazoline class, which is associated with neurologic adverse reactions including seizures. A prior seizure history places the cat in a higher-risk category. Do not administer without explicit veterinary clearance; the treating veterinarian should assess whether an alternative product class is more appropriate.
7. How long does protection against ticks last after a single application?
Each orange-cap pipette provides tick control for one calendar month. The labeled tick species, including Ixodes scapularis and Amblyomma americanum, are covered for this duration under standard monthly dosing. Allow no gap beyond 30 days during peak tick season to maintain uninterrupted protection.
8. Will Revolution Plus 5.6–11 lbs still work if my cat swam the day after treatment?
Yes, provided the cat did not bathe or swim within the first 24 hours after application. Water exposure during that initial 24-hour window reduces selamectin absorption through the skin. Swimming on the day after treatment, once the product is fully dry, does not reduce efficacy and a replacement dose is not needed.
9. Does this product treat an active ear mite infection or only prevent future ones?
Revolution Plus treats active Otodectes cynotis ear mite infestations with a single topical dose applied to the skin at the base of the neck, not directly into the ear canal. Monthly application after the initial treatment dose controls subsequent infestations. If debris is present in the ear canal, cleansing the affected ears is recommended alongside treatment.
10. Can Revolution Plus 5.6–11 lbs be applied to a cat that also receives other medications?
The prescribing information does not list specific drug interactions for Revolution Plus. Cats on concurrent medications, particularly those affecting the central nervous system or liver enzyme pathways, should be assessed by a veterinarian before adding an isoxazoline-class compound to their treatment protocol.
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