Revolution Topical Solution For Dogs 20.1-40 lbs (10.1-20 kg)

Description

Revolution Topical Solution For Dogs 20.1-40 lbs (10.1-20 kg) delivers 120 mg selamectin per tube at 120 mg/mL, manufactured by Zoetis for medium-sized dogs in this weight band. The doubled selamectin load relative to the 10.1–20 lbs variant maintains the labeled minimum dose of 2.7 mg/lb (6 mg/kg) across the full weight range, covering five parasite indications through one monthly topical application.

Recommended for

Dogs weighing 20.1–40 lbs (10.1–20 kg), from 6 weeks of age.

Indication/Coverage

For dogs suffering from, or at risk from, mixed parasitic infections, Revolution 20.1–40 lbs is labeled for the following indications:

• Flea prevention and treatment: Kills adult fleas (Ctenocephalides felis) and prevents hatching of flea eggs for 30 days, disrupting the flea life cycle at both the reproductive adult stage and pre-emergent egg stage.
• Heartworm prevention: Eliminates Dirofilaria immitis L3 and L4 larvae acquired from mosquito exposure in the preceding month, stopping larval progression before the worms establish in the pulmonary arteries.
• Ear mite treatment: Treats Otodectes cynotis infestations; a second monthly dose is required in some dogs to achieve complete resolution, with debris clearance from the ear canal recommended after the second application.
• Sarcoptic mange treatment: Treats Sarcoptes scabiei infestation; a second monthly dose may be necessary, with resolution of pruritus documented in approximately 50% of dogs by day 30 after the initial treatment.
• Tick control: Controls Dermacentor variabilis infestations on a monthly basis; a supplemental dose administered two weeks after the first application is warranted in heavy infestations, after which monthly dosing continues from that point.

Key Benefits

The benefits listed below are grounded in the Zoetis product label for the 120 mg selamectin tube covering dogs in the 20.1–40 lbs weight band:

• Appropriate from 6 weeks: Dogs at the lower boundary of 20.1 lbs (10.1 kg) from 6 weeks of age are within the labeled safety range, with no adverse reactions observed in studies administering selamectin at 10 times the recommended dose to dogs of this age.
• Five indications, one tube: A single monthly application addresses fleas, immitis larvae, ear mites, sarcoptic mange, and D. variabilis ticks, eliminating the need to track separate product schedules for each parasite category.
• Systemic reach via skin absorption: Selamectin distributes systemically after transdermal uptake, allowing it to reach immitis larvae circulating in the bloodstream without requiring oral ingestion or gastrointestinal processing.
• Persistent flea egg suppression: By preventing flea egg viability for a full 30-day interval, Revolution progressively reduces the environmental flea reservoir with each successive dose, rather than relying solely on adult kill.
• Labeled supplemental dosing for heavy tick burden: For dogs in high variabilis pressure environments, a second application at two weeks post-initial dose is protocol-supported on the Zoetis label, providing a documented pathway for intensified tick management.
• Monthly schedule consolidation: All five parasite indications align to a single 30-day dosing interval, avoiding the scheduling complexity that arises when combining multiple single-indication products with differing treatment frequencies.
• Topical route eliminates oral compliance risk: Spot-on delivery at the base of the neck removes the variables of tablet ejection, incomplete chewing, or post-ingestion vomiting that can compromise the bioavailability of oral antiparasitic formats.

Caution

Hazards to Humans

Revolution is flammable and causes eye irritation on direct contact. Keep away from open flame, avoid contact with skin and clothing, and wash hands immediately after handling. Store out of children’s reach and away from all food preparation surfaces and utensils.

Hazards to Domestic Animals

Revolution is for external use only and must not be ingested. This tube is labeled for dogs at or above 20.1 lbs (10.1 kg) from 6 weeks of age; do not administer to animals below either threshold. Sick, debilitated, aged, dogs should be assessed by a veterinarian before the first dose. Sensitivity reactions have been documented in avermectin-sensitive collies at the standard labeled dose. Concurrent use with other macrocyclic lactone products requires prior veterinary review to avoid additive systemic exposure.

Possible Side Effects

Monitor your dog after each application of Revolution 20.1–40 lbs, with particular attention during the first treatment cycle. The following reactions are drawn from post-approval adverse event data reported to the FDA/CVM:

Dermal reactions at the application site encompass transient localized alopecia, erythema, pruritus, vesicles, blisters, and excoriations; these are generally self-limiting and confined to the treated area. Gastrointestinal signs on record include vomiting, loose stool or diarrhea, and hypersalivation. Systemic signs documented in post-approval reporting cover lethargy, anorexia, generalized pruritus, seizures, tremors, ataxia, and dermatitis.