Revolution for Puppies & Kittens up to 5 lbs (up to 2.5 kg)

Description

Revolution for Puppies & Kittens up to 5 lbs (up to 2.5 kg) delivers selamectin, a macrocyclic lactone compound, in a single 0.25 mL topical dose containing 15 mg of active ingredient. Manufactured by Zoetis and approved under FDA NADA #141-152, this formulation provides monthly protection against fleas, heartworm, ear mites, and additional parasites in young animals that weigh under 5 lbs. Each mauve-capped tube is calibrated to supply the minimum effective dose of 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Recommended for

Puppies from 6 weeks of age and kittens from 8 weeks of age weighing up to 5 lbs (up to 2.5 kg).

Indication/Coverage

Revolution for Puppies & Kittens up to 5 lbs addresses distinct parasite profiles depending on species. The following indications are based on manufacturer labeling from Zoetis:

For puppies suffering from, or at risk from, mixed parasitic infections:

• Flea infestations (Ctenocephalides felis): Kills adult fleas and prevents flea eggs from hatching for one month, interrupting the reproductive cycle before environmental contamination accumulates.
• Heartworm disease (Dirofilaria immitis): Prevents heartworm infection by eliminating tissue-stage larvae (L3 and L4) acquired from mosquito bites within the preceding 30 days.
• Ear mites (Otodectes cynotis): Treats and controls ear mite infestations through systemic distribution of selamectin following topical absorption.
• Sarcoptic mange (Sarcoptes scabiei): Indicated for the treatment and control of sarcoptic mange infestations, with clinical studies showing resolution of pruritus within 30 days of treatment.
• Tick infestations (Dermacentor variabilis): Controls American dog tick infestations through systemic action after the parasite feeds on the treated animal.

For kittens suffering from, or at risk from, mixed parasitic infections:

• Flea infestations (Ctenocephalides felis): Kills adult fleas and halts egg production for a full month, reducing household flea burden at every life stage.
• Heartworm disease (Dirofilaria immitis): Prevents heartworm disease by clearing infective larvae before they mature, administered monthly for continuous protection.
• Ear mites (Otodectes cynotis): Treats and controls ear mite infestations. A single topical dose distributes systemically and reaches concentrations lethal to mites within the ear canal.
• Roundworm (Toxocara cati): Treats and controls intestinal roundworm infections, a particularly common parasitic burden in young kittens acquired through the queen’s milk.
• Intestinal hookworm (Ancylostoma tubaeforme): Treats and controls hookworm infections that cause intestinal blood loss, a condition especially dangerous in lightweight kittens.

Key Benefits

The following characteristics distinguish Revolution for Puppies & Kittens up to 5 lbs from other parasiticides labeled for young animals:

• Early-age eligibility: Approved for puppies as young as 6 weeks and kittens from 8 weeks, one of the lowest minimum age thresholds among multi-parasite topicals.
• Broad-spectrum coverage: A single monthly application targets fleas, heartworm larvae, ear mites, and species-specific intestinal parasites or mange, reducing the need for separate treatments.
• Systemic absorption: Selamectin absorbs through the skin into the bloodstream, reaching parasites internally rather than relying solely on surface contact, which means coat length and grooming habits do not diminish efficacy.
• Rapid flea knockdown: Revolution begins killing adult fleas within 36 hours of application and suppresses egg viability for a full 30-day cycle, disrupting flea population growth before it reaches the environment.
• Monthly dosing schedule: One tube per month maintains consistent selamectin levels, simplifying long-term compliance compared to products requiring quarterly or variable dosing intervals.
• Topical formulation: Applied to the skin at a single point on the back of the neck, which suits puppies and kittens that refuse oral medications or are too small for chewable tablets.
• Water-compatible after drying: Bathing or water exposure 2 hours after application does not reduce efficacy, allowing normal activity once the product has dried at the application site.

Caution

Hazards to Humans

Revolution contains isopropyl alcohol and butylated hydroxytoluene (BHT). Avoid contact with eyes, skin, and clothing. If the product contacts skin, wash the area immediately with soap and water. If eye exposure occurs, flush with water for 5 to 10 minutes and seek medical attention. Keep out of reach of children, and do not contaminate food or food preparation surfaces.

Hazards to Domestic Animals

Revolution is for external use only and should be applied directly to the skin, not given orally. This variant is formulated exclusively for puppies and kittens weighing up to 5 lbs (2.5 kg); animals exceeding this weight require a higher-dose tube matched to their weight band. Do not administer to sick, debilitated, or underweight animals. Individual sensitivity to selamectin, while rare, can occur. If your pet is receiving other medications, confirm with a veterinarian that no drug interactions exist before applying Revolution.

Possible Side Effects

Monitor your puppy or kitten after each application for any changes in behavior or appearance at the treatment site. The following adverse reactions have been documented in pre-approval clinical trials and post-approval reporting to the FDA/CVM:

• Application site reactions: Transient hair loss (alopecia) with or without localized inflammation at the application spot was observed in approximately 1% of treated cats during clinical trials. Redness, mild itching, or slight powdery residue at the site typically resolves within days.
• Gastrointestinal signs: Vomiting, loose stool, diarrhea (with or without blood), reduced appetite, and salivation were reported in 0.5% or fewer of treated animals during pre-approval studies.
• Systemic signs: Lethargy, tachypnea (rapid breathing), and muscle tremors occurred at low frequency during clinical trials. Post-approval adverse event reports for dogs additionally include generalized pruritus, seizures, tremors, and ataxia. Post-approval reports for cats additionally include fever, generalized alopecia, hypersalivation, and seizures.