Revolution Topical Solution For Dogs 40.1-85 lbs (20.1-40 kg)

Description

Revolution Topical Solution For Dogs 40.1-85 lbs (20.1-40 kg) contains 240 mg selamectin per tube at 120 mg/mL, produced by Zoetis for large dogs across a 45-pound weight span. At this selamectin load, the labeled minimum of 2.7 mg/lb (6 mg/kg) is maintained at the lower boundary while remaining within the established safety margin at the upper end, covering five parasite indications through a single monthly topical dose.

Recommended for

Dogs weighing 40.1–85 lbs (20.1–40 kg), from 6 weeks of age.

Indication/Coverage

For dogs suffering from, or at risk from, mixed parasitic infections, Revolution 40.1–85 lbs is labeled for the following treatment and prevention indications:

• Flea prevention and treatment: Kills adult fleas (Ctenocephalides felis) and prevents flea egg hatching for a full 30-day interval, targeting both the reproducing adult population on the host and the pre-emergent egg stage in the surrounding environment.
• Heartworm prevention: Eliminates Dirofilaria immitis L3 and L4 larvae acquired through mosquito exposure in the prior month, interrupting larval development before worms mature and migrate to the pulmonary vasculature.
• Ear mite treatment: Treats Otodectes cynotis infestations; a second monthly dose is required in some dogs, with debris removal from the ear canal recommended following the second application to assess clearance.
• Sarcoptic mange treatment: Treats Sarcoptes scabiei infestation; a second monthly dose may be necessary, with resolution of associated pruritus observed in approximately 50% of dogs by day 30 after the first treatment.
• Tick control: Controls Dermacentor variabilis adult tick infestations on a monthly schedule; a supplemental dose at two weeks post-initial application is appropriate in heavy infestations, after which monthly dosing resumes from that date.

Key Benefits

The following points reflect labeled claims and pharmacological data from the Zoetis product insert for the 240 mg selamectin tube:

• Labeled from 6 weeks: Dogs at the lower bound of 40.1 lbs (20.1 kg) from 6 weeks of age fall within the confirmed safety profile, with no adverse reactions recorded in studies where selamectin was administered at 10 times the recommended dose from this age.
• Five indications per dose: A single tube addresses adult fleas and flea egg suppression, immitis larval elimination, ear mite clearance, sarcoptic mange treatment, and D. variabilis tick control within one monthly application.
• Transdermal systemic distribution: Following dermal absorption, selamectin circulates systemically, reaching immitis larvae in the bloodstream without relying on gastrointestinal uptake or first-pass hepatic processing as oral formats require.
• Flea population attrition over time: By blocking flea egg viability for 30 days per dose, Revolution reduces the viable egg count deposited into the household environment with each successive treatment cycle, progressively lowering reinfestation pressure.
• Protocol-backed supplemental tick dosing: For dogs in high variabilis burden areas, the Zoetis label explicitly supports an additional dose two weeks after the first application, providing a documented basis for intensified tick management rather than an off-label workaround.
• Single-interval scheduling across five parasites: All labeled indications align to a 30-day dosing interval, removing the tracking burden that accumulates when multiple single-indication products with staggered schedules are used alongside one another.
• Topical delivery removes oral compliance variables: Spot-on application at the base of the neck eliminates the risk of dose loss through tablet rejection, incomplete mastication, or post-ingestion vomiting that can undermine systemic bioavailability in oral antiparasitic formats.

Caution

Hazards to Humans

Revolution is flammable and produces eye irritation on direct contact. Avoid skin and clothing exposure during application, wash hands immediately after handling, and keep the product away from open flame, food, and food preparation surfaces. Store all tubes out of children’s reach.

Hazards to Domestic Animals

Revolution is formulated for external application only and must not be orally ingested. This tube is designated for dogs weighing 40.1–85 lbs (20.1–40 kg) from 6 weeks of age; do not administer to animals falling below either the weight or age threshold. Dogs that are sick, debilitated, aged, require veterinary assessment before the first dose is given. Individual sensitivity reactions at the standard topical dose have been documented in avermectin-sensitive collies. Concurrent administration alongside other macrocyclic lactone products must not proceed without prior veterinary review.

Possible Side Effects:

Monitor your dog after each Revolution application, with heightened attention following the initial dose in any new treatment course. Post-approval adverse event data submitted to the FDA/CVM document the following reactions:

Localized dermal reactions at the application site include transient alopecia, erythema, pruritus, vesicles, blisters, and excoriations; these are self-limiting in the majority of reported cases and do not extend beyond the treated area. Gastrointestinal signs encompass vomiting, diarrhea or loose stool, and hypersalivation. Systemic signs on record include lethargy, anorexia, generalized pruritus, seizures, tremors, ataxia, and dermatitis.