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Simparica TRIO Chews for Dogs 22.1-44 lbs (10.1-20 kg)
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BASED IN AUSTRALIA
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Choose based on your dog's weight
Description
Simparica TRIO Chews for Dogs 22.1–44 lbs (10.1–20 kg) is a chewable combination parasiticide manufactured by Zoetis. Each tablet contains 24 mg sarolaner, 0.48 mg moxidectin, and 100 mg pyrantel, delivering broad-spectrum parasite control for dogs within the specified weight range. Monthly administration is effective against flea infestations, six tick species, developing heartworm larvae, and gastrointestinal nematodes, including roundworms and hookworms.
Recommended for
Dogs weighing 22.1 to 44 lbs (10.1 to 20 kg) from 8 weeks of age and older.
Indication/Coverage
For dogs suffering from, or at risk of, mixed parasitic infections, Simparica TRIO extends coverage across the following conditions:
- Heartworm prevention: Prevention of heartworm disease caused by Dirofilaria immitis through elimination of susceptible L3/L4 larval stages..
- Flea treatment and prevention: Elimination of adult fleas (Ctenocephalides felis); prevents re-establishment of flea infestations throughout the monthly dosing cycle.
- Tapeworm prevention: Prevents Dipylidium caninum infections as a direct result of eliminating Ctenocephalides felis vector fleas on the treated dog.
- Tick treatment and control: Treatment and control of infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick).
- Lyme disease prevention: Prevents Borrelia burgdorferi infection as a direct result of eliminating Ixodes scapularis vector ticks on the treated dog.
- Roundworm treatment and control: Treatment and control of Toxocara canis (immature adults and adults) and Toxascaris leonina (adults).
- Hookworm treatment and control: Treatment and control of Ancylostoma caninum (L4 larvae, immature adults, and adults) and Uncinaria stenocephala (adults).
Key Benefits
The following characteristics are established by the Zoetis product label and supporting clinical data for dogs in the 22.1 to 44 lb weight band:
- Consolidated monthly coverage: A single tablet per month addresses fleas, six tick species, heartworm larvae, intestinal roundworms, hookworms, tapeworm prevention, and Lyme disease risk, consolidating what would otherwise require multiple products on separate schedules.
- Approved from 8 weeks: Dogs as young as 8 weeks and weighing at least 22.1 lbs (10.1 kg) are eligible, ensuring prevention can begin as soon as body weight enters this band without waiting for further maturation.
- Early flea kill onset: Simparica TRIO begins eliminating adult fleas at 4 hours post-dosing and achieves 100% efficacy at 8 hours, curtailing flea egg production on the day of administration.
- Full-interval tick control: Against scapularis, the product reduces live tick burden by at least 94.2% within 24 hours of re-infestation and sustains this level of efficacy across the 28-day dosing interval, limiting cumulative pathogen exposure between monthly doses.
- Hookworm clearance across three life stages: Pyrantel pamoate acts as a depolarizing neuromuscular blocker in susceptible nematodes, achieving documented clearance of caninum at L4, immature adult, and adult stages within a single treatment cycle.
- Vector-borne disease interruption: Two controlled laboratory studies confirmed that Simparica TRIO prevented Borrelia burgdorferi transmission following scapularis infestation at 28 days post-treatment, a meaningful outcome for medium-sized dogs with outdoor or trail access.
- Oral route for active dogs: Medium-sized dogs in this weight range are frequently bathed, swim regularly, or are physically active outdoors; the oral chewable format maintains full efficacy regardless of water exposure or coat condition.
- Environmental flea burden reduction: In a controlled study, Simparica TRIO eliminated fleas before egg deposition occurred for 35 consecutive days, limiting the accumulation of viable flea eggs in the home between monthly doses.
Caution
Hazards to Humans
Keep out of reach of children. Simparica TRIO is formulated for oral administration to dogs; accidental human ingestion requires immediate medical attention. Wash hands after handling tablets and prior to any food contact. Do not transfer tablet fragments to eyes or open skin.
Hazards to Domestic Animals
Simparica TRIO is for oral use in dogs only; do not administer to cats or other species. This variant is not appropriate for dogs below 22.1 lbs (10.1 kg) or younger than 8 weeks of age. Sarolaner is an isoxazoline-class compound associated with neurologic adverse reactions including tremors, ataxia, and seizures; use with caution in dogs with a history of seizures or neurological disorders. The safety of Simparica TRIO has not been established in breeding, pregnant, or lactating dogs; consult a veterinarian before use in these animals. Dogs that are debilitated or on concurrent medications should be evaluated by a veterinarian before administration.
Possible Side Effects
Monitor your dog closely following each Simparica TRIO administration, with heightened attention during the 24 to 48 hours after the first dose.
The adverse reactions below were documented across three field safety studies conducted by Zoetis; incidence figures are drawn from the primary study of 272 dogs receiving monthly treatment for up to 11 cycles:
- Vomiting: Reported in 14.3% of treated dogs in the principal study; consistently the most frequently recorded reaction across all three field studies, including those involving dogs with active flea and roundworm burdens.
- Diarrhea: Observed in 13.2% of treated dogs, with or without blood in post-approval reporting; rates were elevated in dogs carrying concurrent roundworm infections at the time of first administration.
- Lethargy: Recorded in 8.5% of treated dogs; typically transient and resolving without intervention.
- Anorexia: Reported in 5.1% of treated dogs, at a frequency consistent with the active control group.
- Polyuria: Observed in 3.7% of treated dogs within the primary field study population.
- Hyperactivity: Reported in 2.2% of Simparica TRIO-treated dogs, compared to 0.7% in the active control group.
- Seizures: Confirmed in one dog in a controlled laboratory study 16 days after dosing; post-approval FDA/CVM adverse event data identify seizure as a class-level risk for all isoxazoline compounds.
- Muscle tremors and ataxia: Recorded in post-approval adverse drug experience reports filed with FDA/CVM; reliable incidence estimates cannot be derived from spontaneous post-market reporting alone.
If any of these signs emerge or worsen after dosing, stop administration and contact a veterinarian.
Direction
Simparica TRIO Chews for Dogs 22.1-44 lbs (10.1-20 kg) is given orally as a single flavored chewable tablet, once per month. Administer the tablet directly to the dog or with a small portion of food if needed. Ensure complete consumption of the tablet, including any portions divided to aid intake, before concluding the dose. In homes with multiple pets, prevent access by other animals during administration and for a brief period afterward to ensure the medication is consumed only by the intended dog.How to Open
- Detach a single blister unit from the strip.
- Begin opening at the arrow-marked corner.
- Peel away the protective backing.
- Lift the tablet out of the blister cavity.
How to Administer
- Confirm your dog's weight on the day of dosing and ensure it falls within the 22.1–44 lb weight range prior to opening the blister pocket.
- Administer the tablet directly or provide it with a small portion of food.
- If voluntary consumption is not achieved, the tablet may be broken into smaller pieces. Verify that all portions have been consumed before considering the dose complete.
- Observe the dog following administration. If vomiting occurs within 1 hour, seek veterinary guidance regarding the need for re-dosing.
- Document the dosing date and administer the next dose on the corresponding date of the following month.
Storage
- Keep out of reach of children and pets.
- Store at or below 30°C (86°F).
- Do not administer after the expiry date printed on the packaging; the expiry date refers to the last day of the stated month.
- Keep tablets in the original blister card until immediately before use to protect against moisture and physical damage.
Tips for Using
- Maintain a monthly schedule: Give the tablet on the same calendar day each month to ensure uninterrupted heartworm prevention. Avoid calculating doses every 30 days, as timing can gradually shift.
- Monitor your dog’s weight: Growing dogs may outgrow their current dosage strength. Check weight before each treatment and switch to the 1-88 lb tablet once your dog exceeds 44 lbs.
- Do not share doses: Each tablet is intended for a single pet. Splitting a tablet between animals can result in inadequate protection, although dividing it for one dog is acceptable if the entire dose is consumed.
- Missed a treatment? Administer the dose as soon as possible and use that date as the starting point for future monthly doses. Do not give extra medication to make up for a missed dose.
- Offer with food: Giving the chewable during or shortly after a meal may improve acceptance and help minimize gastrointestinal upset.
- Verify full consumption: Ensure your dog eats the entire tablet, including any broken pieces, so the full prescribed dose is received.
- Vomiting after administration: If your dog vomits within the first hour, consult your veterinarian about whether another dose is necessary. Vomiting later than two hours after dosing is less likely to impact efficacy.
- Treat all pets in the home: Parasites can continue circulating among untreated animals. Keeping every pet on an appropriate prevention program helps reduce the risk of reinfestation.
| Product Name | Simparica TRIO Chewable Tablets for Dogs 22.1-44 lbs (10.1-20 kg) |
|---|---|
| Target Weight | 22.1 – 44 lbs (10.1 – 20 kg) |
| Packaging Color | Blue |
| Active Ingredients | Moxidectin 0.48 mg, Pyrantel 100 mg, Sarolaner 24 mg |
| Application Type | Pork liver-flavored chewable tablet |
| Appearance | A pentagonal, reddish brown chewable tablet |
| Administration Route | Oral administration; for dogs only |
| Pack Sizes Available | 1, 3, or 6 chewable tablets per package |
| Treatment Frequency | Once monthly; single dose also treats existing roundworm and hookworm infections |
| Effective Against | – Fleas (Ctenocephalides felis, adult) |
| Storage | At or below 30°C (86°F) |
FAQs
1. My dog weighs exactly 22.1 lbs today. Is the blue tablet the correct choice?
Yes. The 22.1 to 44 lb tablet (sarolaner 24 mg / moxidectin 0.48 mg / pyrantel 100 mg) is labeled for dogs at exactly 22.1 lbs (10.1 kg). Dogs that have not yet reached 22.1 lbs on the treatment day should remain on the 11.1–22 lb variant until that threshold is confirmed. Weigh on the day of dosing before opening the blister card. Dogs exceeding 44 lbs (20 kg) should move to the next weight-band tablet. Simparica TRIO is available in five other weight-based variants:
- Simparica TRIO Chews for Dogs 2.8–5.5 lbs (1.25–2.5 kg)
- Simparica TRIO Chews for Dogs 5.6–11 lbs (2.6–5 kg)
- Simparica TRIO Chews for Dogs 11.1–22 lbs (5.1–10 kg)
- Simparica TRIO Chews for Dogs 44.1–88 lbs (20.1–40 kg)
- Simparica TRIO Chews for Dogs 88.1–132 lbs (40.1–60 kg)
2. Is 24 mg sarolaner safe for a 22.1 lb dog?
Yes. Zoetis margin-of-safety studies dosed 8-week-old Beagle puppies at 1×, 3×, and 5× the maximum labeled dose across seven 28-day treatment cycles. No clinically relevant adverse effects were observed on clinical signs, body weight, hematology, or histopathology at any dose level. The 24 mg tablet provides the labeled sarolaner dose for dogs weighing 22.1–44 lb and falls within the dosing range evaluated in safety studies.
3. My dog just exceeded 22 lbs and graduated from the orange tablet. Should I switch to the blue tablet right away?
Yes, switch at the next dose. Once body weight exceeds 22 lbs (10 kg), the 11.1–22 lb tablet delivers all three active ingredients below the minimum therapeutic concentration per kilogram, which reduces efficacy against fleas, ticks, and heartworm larvae. Move to the 22.1–44 lb tablet at the next scheduled monthly administration, or sooner if the dosing gap would otherwise surpass 30 days.
4. I missed my 30 lb dog’s monthly Simparica TRIO dose by two weeks. What should I do?
Administer the 22.1 to 44 lb tablet immediately and reset the monthly schedule from that new date. Do not give two tablets to make up for the missed interval. If the dog lives in a heartworm-endemic area and has confirmed mosquito exposure during the lapse, consult a veterinarian to assess whether the gap in coverage warrants further evaluation.
5. My 35 lb dog has a history of neurological episodes. Can he take Simparica TRIO?
Consult a veterinarian before initiating treatment. Sarolaner is an isoxazoline-class compound; neurologic adverse reactions including tremors, ataxia, and seizures have been reported in dogs receiving isoxazoline-class drugs, including dogs without a prior seizure history. A veterinarian should determine whether a non-isoxazoline prevention protocol is more appropriate given the dog’s neurological background.
6. Can I give my 28 lb dog Simparica TRIO if she is currently nursing a litter?
The safety of Simparica TRIO in lactating dogs has not been evaluated by Zoetis. Use in nursing animals falls outside the scope of the product label; consult a veterinarian to identify an alternative prevention protocol with established safety data for lactating dogs before administering Simparica TRIO.
7. My 40 lb dog swims several times a week. Does water exposure reduce Simparica TRIO’s efficacy?
No. Because Simparica TRIO is an oral chewable that acts systemically via bloodstream distribution, water exposure has no effect on its efficacy against fleas, ticks, or any other covered parasite. This is a practical advantage for active dogs in this weight range that spend significant time in water.
8. Does my 25 lb dog need a heartworm test before starting Simparica TRIO?
Yes. The Zoetis label specifies that all dogs should be tested for existing D. immitis infections prior to initiating any heartworm prevention protocol. Simparica TRIO does not eliminate established adult heartworms; administering moxidectin to a dog with circulating microfilariae may trigger a transient febrile reaction as microfilaria counts fall rapidly. A veterinarian should confirm the dog is antigen-negative before the first dose.
9. My 32 lb dog vomited about 2 hours after taking the blue tablet. Was the dose absorbed?
Vomiting at 2 hours post-administration may represent partial dose loss. Sarolaner reaches mean peak plasma concentration at approximately 3.5 hours after oral dosing, so absorption was likely still in progress at the point vomiting occurred. Contact a veterinarian to assess whether the quantity absorbed was sufficient or whether re-dosing is warranted rather than assuming full efficacy.
10. Can I use the 22.1–44 lb Simparica TRIO tablet for my 43 lb dog that also receives monthly joint supplements?
Field safety studies confirmed that Simparica TRIO was co-administered with a range of medications including anti-inflammatory agents without observed interaction-related adverse events. Joint supplements were not among the evaluated combinations in the label studies; confirm the specific supplement formulation with a veterinarian before concurrent use, particularly if it contains pharmacologically active compounds rather than standard nutritional ingredients.
14 reviews for Simparica TRIO Chews for Dogs 22.1-44 lbs (10.1-20 kg)
| 5 star | 78% | |
| 4 star | 14% | |
| 3 star | 7% | |
| 2 star | 0% | |
| 1 star | 0% |
1-5 of 14 reviews
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We’ve been using this brand since before our pups were even born. We completely trust it, and Bella has no problem taking the chewable pill. She’s never had issues with fleas, ticks, or heartworms.
This product is worth every penny. Our dog is more active and playful now that he’s not dealing with flea bites.
The convenience of a chewable tablet that covers fleas, ticks, and heartworms is unbeatable. Our dog loves it, and so do we.
Living in Alberta, we trust this product to protect our dog from heartworms.
Giving my dog heartworm medication used to be a struggle. These chewables are a breeze, he gobbles them right up. Highly recommend for easy heartworm prevention.