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Stronghold Plus For Cats 11-22 lbs (5-10 kg)
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Description
Stronghold Plus For Cats 11-22 lbs (5-10 kg) from Zoetis is a monthly spot-on solution covering the largest standard weight band in the cat range. Each green-capped pipette delivers 60 mg selamectin and 10 mg sarolaner in 1 ml, satisfying the minimum therapeutic dose of 6 mg/kg selamectin and 1 mg/kg sarolaner across the full 5–10 kg range. This variant is indicated exclusively where tick control is required at the same time as one or more additional parasite targets.
Recommended for
Cats weighing 11–22 lbs (5–10 kg) from 8 weeks of age.
Indication/Coverage
For cats suffering from, or at risk from, mixed parasitic infections:
- Flea treatment and prevention (Ctenocephalides spp.): adulticidal activity eliminates fleas within 24 hours of application; ovicidal and larvicidal action sustains flea lifecycle interruption for 5 weeks per dose
- Flea allergy dermatitis (FAD): applicable as one component of a broader treatment strategy where confirmed flea infestation drives the allergic response
- Tick treatment (Ixodes ricinus, Ixodes hexagonus): persistent acaricidal activity for 5 weeks; efficacy against Dermacentor reticulatus and Rhipicephalus sanguineus extends to 4 weeks per dose
- Ear mite treatment (Otodectes cynotis): single-dose administration; veterinary re-examination at 30 days determines whether a second application is warranted
- Biting lice treatment (Felicola subrostratus): single-dose administration
- Adult roundworm treatment (Toxocara cati): targets adult-stage intestinal nematodes
- Adult hookworm treatment (Ancylostoma tubaeforme): targets adult-stage intestinal nematodes
- Heartworm prevention (Dirofilaria immitis, L3/L4 larvae): monthly dosing arrests larval development before maturation to adult worms; this product carries no activity against established adult heartworm infections
Key Benefits
Stronghold Plus for cats 11–22 lbs delivers the following clinically documented actions:
- Parallel kill mechanisms: selamectin (avermectin class) disrupts chloride channel conductance in invertebrate nerve and muscle tissue, while sarolaner (isoxazoline class) blocks GABA- and glutamate-gated chloride channels in arthropods, giving the formulation two independent routes of parasite elimination per dose
- Full flea lifecycle control: adult fleas are killed within 24 hours, and concurrent ovicidal and larvicidal activity prevents egg hatching and larval survival, breaking the reproductive cycle and progressively reducing environmental flea burden over the 5-week protection window
- Four-species tick coverage: sarolaner delivers acaricidal onset against ricinus within 24 hours of attachment, with protection sustained for 5 weeks against I. ricinus and I. hexagonus, and 4 weeks against D. reticulatus and R. sanguineus
- Heartworm larval interception: selamectin eliminates immitis L3 and L4 larvae before they can develop into adult worms; the preventive action depends on uninterrupted monthly dosing
- Intestinal nematode treatment: a single dose addresses adult Toxocara cati and Ancylostoma tubaeforme, extending utility beyond ectoparasite management without requiring a separate worming product for these two species
- Topical format: spot-on delivery bypasses the need for oral administration, which is a practical distinction for larger cats that are difficult to medicate orally
- Suitable from 8 weeks: labeled use begins at 8 weeks and a minimum body weight of 1.25 kg; cats in the 11–22 lbs range that have been on Stronghold Plus since kittenhood can continue on the appropriately sized pipette without interruption as they grow through weight bands
- Documented overdose margin: Zoetis safety data show no clinically significant adverse reactions in kittens treated at up to 5 times the maximum recommended dose across 8 consecutive monthly applications; this margin does not permit exceeding labeled dosing
Caution
Hazards to Humans
This product is harmful if ingested and causes eye irritation on contact. Avoid touching the face or eyes during and after application, and wash hands with soap and water immediately afterward. Children must not handle or play with treated cats for at least 4 hours, and treated animals should not share a sleeping space with children on the night of treatment.
Hazards to Domestic Animals
For external use only; oral or parenteral administration is not permitted. This variant is labeled for cats aged at least 8 weeks and weighing a minimum of 1.25 kg. Do not apply to cats that are debilitated, concurrently ill, or underweight relative to their age and size. Sarolaner safety in pregnant or lactating cats has not been confirmed; use in these animals requires a veterinarian’s benefit-risk assessment. Individual sensitivity is possible in any cat, and a veterinarian should be consulted where concurrent medications are in use.
Possible Side Effects
Monitor your cat for 24 to 48 hours after each application, paying particular attention following the first dose in a new treatment course.
The reactions below have been documented in clinical trial data and post-marketing surveillance:
- Application-site pruritus: mild, transient itching at the spot-on location is the most frequently reported finding; it resolves without treatment in the majority of cats and does not indicate a need to discontinue
- Localised alopecia: mild to moderate hair loss at the point of application has been recorded as an uncommon event; it typically resolves within one to two treatment cycles
- Erythema: localised skin reddening at the application site is classified as uncommon and self-limiting in reported cases
- Drooling (hypersalivation): results from the cat grooming the application area before the product has dried; applying at the correct site at the base of the neck in front of the shoulder blades substantially limits the cat’s ability to reach the wet solution
- Transient gastrointestinal signs: if significant oral ingestion of the product occurs, hypersalivation, vomiting, soft faeces, and reduced appetite may follow; these effects are expected to resolve without treatment
Seek veterinary attention if any reaction persists beyond 48 hours, escalates in severity, or is accompanied by systemic signs such as tremor, altered gait, or marked behavioural change.
Direction
Apply Stronghold Plus For Cats 11-22 lbs (5-10 kg) as a topical spot-on to bare skin at the base of the cat's neck, directly in front of the shoulder blades. Deposit the full 1 ml volume at one site without rubbing or spreading; massaging the solution disperses it across hair fibres rather than concentrating it on skin, which reduces the effective absorbed dose. Keep the cat away from heat sources and open flames for at least 30 minutes after application or until the coat is fully dry. In multi-pet households, isolate the treated cat from other animals until the application area is dry to prevent secondary ingestion through coat contact.How to Open
- Remove the pipette from the blister pack immediately before use; the foil packaging should remain intact until the moment of application.
- Hold the pipette upright with the cap oriented away from you.
- Press the cap firmly downward to puncture the inner applicator seal.
- Rotate and pull the cap free to expose the pipette tip for application.
How to Administer
- Confirm the coat is completely dry before beginning; wet fur impairs dermal absorption of both selamectin and sarolaner and reduces the dose effectively delivered to the cat.
- Using your fingers, part the fur at the base of the neck in front of the shoulder blades until a clear area of bare skin is exposed.
- Press the pipette tip directly against the skin and squeeze firmly until the pipette is completely empty, concentrating the full 1 ml volume at that single site.
- Avoid skin contact with the solution; if it occurs, wash the affected area with soap and water immediately.
- Keep the cat away from other animals and out of reach of children until the application site is fully dry.
Storage
- Store all pipettes below 30°C (86°F) and keep each one in its individual blister packaging until immediately before use.
- The expiry date is printed on the blister after "EXP" and refers to the last day of that stated month; do not administer after this date.
- Keep out of reach of children at all times.
- Dispose of used pipettes with household refuse rather than via wastewater, as selamectin is harmful to aquatic organisms.
Tips for Using
- Check your cat’s size before application: This pipette is designed for cats weighing 11-22 lbs (5-10 kg) and should only be used in cats 8 weeks of age or older.
- Ensure the coat is completely dry: Apply the treatment only when your cat’s fur and skin are dry, as applying to a wet coat may affect the absorption of the active ingredients and reduce treatment performance.
- Open the pipette as instructed: Hold the pipette upright and press the cap down firmly to puncture the seal inside the tube. Remove the cap before applying the product.
- Apply to the correct location: Place the solution directly onto the skin at the base of the neck, between or just in front of the shoulder blades, where your cat cannot easily lick the treatment.
- Expose the skin properly: Part the fur carefully until the skin is visible. For the treatment to work effectively, the liquid must make direct contact with the skin rather than remaining on the hair.
- Apply the entire contents: Position the tip of the pipette against the exposed skin and squeeze firmly several times (about 3–4 squeezes) until the pipette is completely empty.
- Do not rub the application site: Let the product dry naturally. Rubbing or massaging the area can remove some of the solution and may decrease the amount absorbed.
- Keep pets apart until the area is dry: Prevent other household pets from grooming or licking the treated area, as ingesting the product may lead to temporary gastrointestinal discomfort.
- Limit children’s interaction: Avoid allowing children to touch the treated cat for at least 4 hours after application, and do not allow the cat to sleep with children on the evening of treatment.
- Apply the treatment at night if possible: Evening application helps reduce unnecessary contact while the product dries and follows the manufacturer’s recommended usage guidance.
- Maintain regular monthly treatment: Use one pipette every 30 days to provide continuous protection against fleas, ticks, and heartworms. For conditions such as ear mites, biting lice, and certain intestinal worms, a follow-up evaluation after 30 days may be recommended to determine whether additional treatment is required.
| Product Name | Stronghold Plus for Cats 11-22 lbs (5-10 kg) |
|---|---|
| Target Weight | 11 – 22 lbs (5 – 10 kg) |
| Packaging Color | Green |
| Pipette Volume | 1.0 ml |
| Active Ingredients | Sarolaner 10 mg, Selamectin 60 mg |
| Key Excipients | Butylated hydroxytoluene 0.2 mg/ml, dipropyleneglycol monomethyl ether, isopropyl alcohol |
| Application Type | Topical spot-on solution applied directly to bare skin at the base of the neck |
| Appearance | Clear, colourless to yellow solution |
| Administration Route | For external use only |
| Pack Sizes Available | 3-pack or 6-pack pipettes |
| Treatment Frequency | Monthly for fleas, ticks, and heartworm prevention; single dose for ear mites, biting lice, roundworm, and hookworm |
| Effective Against | – Fleas (Ctenocephalides spp., adults, eggs, larvae) |
| Storage | Below 30°C (86°F); do not remove from blister until ready to use |
FAQs
1. My cat weighs exactly 5 kg, is the green-cap pipette the right choice?
No. A cat at exactly 5 kg falls within the orange-cap range and should continue with the orange-cap 2.5–5 kg variant. The green-cap pipette (60 mg selamectin / 10 mg sarolaner) is labeled for cats over 5 kg up to 10 kg; a cat that has not yet exceeded 5 kg on treatment day does not qualify for this variant. Weigh on the day of treatment before selecting the pipette. Stronghold Plus is available in two other weight-based variants for cats:
- Stronghold Plus For Cats Up to 5.5 lbs (up to 2.5 kg)
- Stronghold Plus For Cats 5.5–11 lbs (2.5–5 kg)
2. Is 60 mg selamectin safe for a cat just 5.1 kg, at the lower end of this range?
Yes. At 5.1 kg, the 60 mg selamectin / 10 mg sarolaner dose delivers 11.8 mg/kg selamectin and 1.96 mg/kg sarolaner, both above the minimum labeled thresholds of 6 mg/kg and 1 mg/kg respectively. Zoetis safety data confirmed no clinically significant adverse reactions in kittens dosed at up to 5 times the maximum recommended level across 8 consecutive monthly treatments. Do not apply this pipette to a cat weighing 5 kg or below; the orange-cap variant is the appropriate choice for those animals.
3. My cat just exceeded 5 kg, do I switch to the green-cap pipette at the next dose?
Yes, switch at the very next application. Once your cat’s verified weight exceeds 5 kg, the orange-cap pipette no longer delivers selamectin or sarolaner at the minimum labeled concentration per kilogram. Continuing with the smaller pipette produces a subtherapeutic outcome against all covered parasites without reducing the dose proportionally. Move to the green-cap 11–22 lbs variant from that treatment date onward.
4. What should I do if I miss a monthly dose for my cat in this weight range?
Apply the missed dose as soon as the gap is identified, then resume the regular 30-day schedule from that revised date. A lapse beyond one month creates a window during which newly acquired D. immitis larvae may advance beyond the L3/L4 stage that selamectin targets. If the interruption spans several months in a heartworm-endemic area, consult a veterinarian about whether testing for adult heartworm infection is appropriate before restarting preventive treatment.
5. My cat weighs over 10 kg, can I use two green-cap pipettes?
A cat exceeding 10 kg falls outside the labeled range for all three standard Stronghold Plus pipette sizes. The SPC states that cats over 10 kg should receive an appropriate combination of pipettes, but the specific combination for any given weight requires a veterinarian’s assessment. Do not self-select a two-pipette combination without veterinary guidance, as the correct dosing calculation depends on the cat’s exact body weight.
6. Can I use the green-cap pipette on my pregnant cat?
Selamectin is considered safe in pregnant cats per Zoetis label data. The safety of sarolaner in pregnant cats has not been fully established; laboratory studies in rats and rabbits showed no teratogenic effects, but this has not been directly confirmed in cats. Use during pregnancy should follow a veterinarian’s individual benefit-risk assessment rather than routine administration.
7. Does Stronghold Plus protect my cat against all ticks in the environment?
Sarolaner is active against Ixodes ricinus, Ixodes hexagonus, Dermacentor reticulatus, and Rhipicephalus sanguineus only; tick species outside this list are not covered by the label. Additionally, sarolaner requires ticks to attach and begin feeding before systemic exposure occurs, so transmission of tick-borne pathogens during the feeding window before kill cannot be fully excluded. Stronghold Plus reduces tick burden and shortens attachment duration but does not prevent initial tick contact.
8. How does Stronghold Plus handle an existing flea infestation in the home environment?
Selamectin has adulticidal, ovicidal, and larvicidal activity. Adult fleas on the cat are killed within 24 hours; eggs produced on the cat and larvae in the immediate environment are also eliminated by selamectin debris shed from the treated animal. This progressive environmental action reduces the flea population in areas the cat accesses over time, though heavily infested environments may require additional environmental treatment alongside ongoing monthly dosing.
9. My cat was treated for ear mites last month, does she still need re-examination?
Yes. The label recommends veterinary re-examination 30 days after the initial ear mite dose to determine whether a second application is necessary. Mite eggs present at the time of treatment may not be fully eliminated by the first dose, and residual adults can re-establish the infestation if left unchecked. Do not assume a single dose has resolved the infestation without follow-up confirmation.
10. Can Stronghold Plus be used alongside other medications my cat is already taking?
No interactions between Stronghold Plus and routinely used veterinary medicinal products were identified during clinical field testing. That said, this finding covers products evaluated in the trial; it does not extend to all possible concurrent medications. If your cat is receiving any ongoing treatment, inform your veterinarian before starting Stronghold Plus to confirm there are no grounds for concern specific to your cat’s medication profile.
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