Simparica Trio is an advanced parasitic treatment for dogs, targeting fleas, ticks, heartworms, and roundworms. Safe for puppies as young as 8 weeks old and weighing at least 2.8 pounds, it provides comprehensive protection with a single monthly dose. This treatment demonstrates 100% effectiveness against heartworm disease after one dose. It begins killing fleas within 4 hours, achieving full efficacy by 8 hours, and is ≥98.9% effective against tick infestations within 48 hours. Additionally, it boasts 99.2% efficacy against adult roundworms with a notable reduction in fecal egg count and over 94% efficacy against hookworms. Regular monthly administration ensures your dog remains safe and healthy, free from harmful parasites.
Simparica Trio contains three active pharmaceutical ingredients: sarolaner, moxidectin and pyrantel pamoate. Sarolaner works by inhibiting neurotransmitters in parasites, leading to their death. Moxidectin interferes with the parasite’s nerve transmission, effectively preventing heartworm. Pyrantel causes spastic paralysis in worms, which helps in treating intestinal worms.
Directions
- Check the weight of your dog before commencing treatment.
- Directly give the Simparica Trio chewable tablet to your dog or mix it with the dog’s meal.
- Ensure your dog consumes the entire Simparica Trio dose.
- Do not split the Simparica Trio tablet; administer it whole.
- Dosage starts with a minimum dose of 11.4 mg/lb (25 mg/kg) of body weight.
- Treatment with Simparica Trio can begin at any time during the year.
Dosage
Administer Simparica according to the following dosage table.
| Dog’s Weight (lbs) | Simparica Trio Tablet Strength (mg) | Pack Color |
| 2.8 – 5.5 | 6 mg Sarolaner / 0.12 mg Moxidectin / 25 mg Pyrantel | Yellow |
| 5.6 – 11.0 | 12 mg Sarolaner / 0.24 mg Moxidectin / 50 mg Pyrantel | Purple |
| 11.1 – 22.0 | 24 mg Sarolaner / 0.48 mg Moxidectin / 100 mg Pyrantel | Orange |
| 22.1 – 44.0 | 48 mg Sarolaner / 0.96 mg Moxidectin / 200 mg Pyrantel | Green |
| 44.1 – 88.0 | 96 mg Sarolaner / 1.92 mg Moxidectin / 400 mg Pyrantel | Blue |
| 88.1 – 132.0 | 144 mg Sarolaner / 2.88 mg Moxidectin / 600 mg Pyrantel | Brown |
Benefits
- Provides 100% efficiency against fleas within 8 hours of administration.
- A single dose prevents fleas for a full month.
- Within 24 hours, it significantly reduces the number of fleas and ticks on dogs.
- Prevents flea allergy dermatitis and improves signs of flea allergy dermatitis in dogs.
- No need for monthly administration or dealing with messy topical applications.
- Reduces gaps in protection against flea and tick infestations.
- The chewable tablet has a palatable taste, making it easy to administer.
- Treats lone star ticks for up to 8 weeks.
Safety
- Simparica Trio is strictly recommended for veterinary use only.
- Keep the product away from children.
- Do not eat, drink, or smoke while administering the product.
- After treatment, immediately wash your hands with soap and water.
- Store at a controlled room temperature of 59-86° F (15-30° C).
Warnings:
- Before starting the treatment, consult your vet if your dog has a history of epilepsy, seizures, ataxia, or muscle tremors.
- If your dog experiences vomiting, diarrhea, lethargy, decreased appetite, flatulence, or polydipsia, contact a vet immediately.
Frequently Asked Questions
What happens if a dose is missed, or a dog vomits after administration?
If a dose is missed, administer a new dose immediately. If a dose is vomited or spit out, administer another dose. Continue with the regular monthly dosing schedule afterward.
Why should I recommend Simparica Trio or Simparica?
Both Simparica Trio and Simparica are highly palatable chews that protect dogs against ticks and fleas. Simparica Trio, however, also includes moxidectin and pyrantel, providing additional protection against heartworm disease, roundworms, and hookworms.
Is it safe to administer Simparica Trio alongside other heartworm, tick, or flea medications?
No studies have been conducted to evaluate the concurrent use of Simparica Trio with other medications. However, Simparica Trio effectively protects against heartworm disease, ticks, and fleas with just one chewable, eliminating the need for additional products.
What are the concerns with Simparica Trio for dogs?
Simparica may cause neurological signs such as tremors, unsteadiness, and seizures in dogs, with or without a history of neurological disorders. It has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions observed in clinical trials were vomiting and diarrhea.
Can I buy Simparica Trio without a vet prescription?
Yes, you can buy Simparica Trio without a prescription at AnipetShop. As a reputable pet medicine supplier, we source and deliver this product from regions where it is available over-the-counter and rigorously verify each batch for quality.
Should I give my dog Simparica Trio every month?
Yes, Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
Can Simparica Trio tablets be split for administration?
No, Simparica Trio chewables are not scored and should not be divided.
Can Simparica Trio be used for cats?
No, Simparica Trio is only approved for use in dogs.