Frontline Plus for Dogs 23-44 Lbs (10-20 Kg)

Description

Frontline Plus for Dogs 23–44 Lbs (10–20 Kg) delivers two active compounds in a single 1.34 ml spot-on pipette: fipronil (134 mg), a phenylpyrazole ectoparasiticide, and (S)-methoprene (120.60 mg), a juvenile hormone analogue that suppresses flea egg viability and larval maturation. Boehringer Ingelheim manufactures this formulation under the same specifications dispensed at veterinary clinics worldwide. Each monthly application sustains adult flea kill for up to eight weeks while simultaneously preventing environmental reinfestation by rendering flea eggs and larvae nonviable.

Recommended for

Dogs weighing 23 to 44 lbs (over 10 kg up to 20 kg), from 8 weeks of age.

Indication/Coverage

For dogs suffering from, or at risk from, mixed ectoparasitic infestations:

• Treatment of flea infestations (Ctenocephalides spp.), adults: Fipronil destroys adult fleas through direct neurotoxic contact. Residual insecticidal activity against newly acquired adult fleas extends for eight weeks following a single dose.
• Prevention of flea reproduction, eggs/larvae/pupae: (S)-methoprene penetrates the eggshell of freshly laid flea eggs or absorbs through the cuticle of adult fleas, blocking development of immature stages for eight weeks and curtailing household contamination.
• Treatment of tick infestations (Rhipicephalus sanguineus, Dermacentor variabilis, Amblyomma americanum, Ixodes scapularis): A single application controls all life stages of ticks. Attachment of individual ticks remains possible, and transmission of tick-borne diseases, including Lyme disease, Rocky Mountain Spotted Fever, ehrlichiosis, babesiosis, haemobartonellosis, and anaplasmosis , cannot be entirely ruled out under unfavorable conditions.
• Treatment of biting lice infestations (Trichodectes canis), adults: Fipronil targets the louse nervous system on contact, disrupting chloride ion transfer and causing rapid paralysis.

Key Benefits

The following characteristics define this weight-band formulation:

• Medium-breed coverage: The 1.34 ml pipette is calibrated for dogs over 10 kg up to 20 kg, encompassing breeds such as Beagles, Cocker Spaniels, and Shetland Sheepdogs at adult weight.
• Dual-target formulation: Fipronil acts on the adult parasite nervous system while (S)-methoprene independently arrests egg, larval, and pupal development, addressing two distinct stages of the flea lifecycle in parallel.
• Contact kill mechanism: Fipronil spreads across the skin surface via natural lipid redistribution. Ectoparasites are exposed through direct contact with treated skin and coat, without requiring a blood meal.
• Rapid flea elimination: Fleas are killed within 24 hours of exposure; ticks and biting lice within 48 hours.
• Extended flea suppression: A single application inhibits flea multiplication for up to eight weeks through combined ovicidal and larvicidal activity, reducing the reservoir of immature fleas in carpets, bedding, and resting areas.
• Tick protection for four weeks: Acaricidal efficacy against four labeled tick species persists through the monthly dosing interval.
• Non-systemic delivery route: The product remains on the skin and hair coat rather than entering the bloodstream. This topical format circumvents gastrointestinal absorption, making it an appropriate alternative for dogs that reject oral chewables or experience vomiting after ingestion.

Caution

Hazards to Humans

This product is a mucous membrane, skin, and eye irritant. Avoid oral, dermal, and ocular contact during handling. Seek immediate medical attention if accidentally ingested, presenting the package insert to the attending physician. Wash hands thoroughly after application. Do not consume food, beverages, or tobacco products while administering the dose. Children should not handle treated dogs until the application site is fully dry.

Hazards to Domestic Animals

Frontline Plus is restricted to external topical use. Do not apply to puppies younger than 8 weeks or to animals that are febrile, systemically unwell, or convalescing from illness. This formulation is developed exclusively for dogs; applying it to cats, ferrets, or rabbits risks overdosing and can cause fatal reactions in rabbits. Individuals, whether animal or human, with documented hypersensitivity to insecticides or alcohol carriers should not come into contact with this product. Consult a veterinarian before treating debilitated, aged, pregnant, or lactating dogs. Do not combine with other topical flea treatments applied directly to the skin, as concurrent use has not been assessed for safety or potential drug interaction.

Possible Side Effects

Monitor your dog closely following each application for behavioral shifts or skin changes at and around the treated area. Adverse reactions are classified as very rare based on post-market surveillance data.

Reported reactions grouped by system include:

• Dermal reactions: Temporary skin discoloration, focal hair loss, itching, and redness at the application site. In isolated instances, generalized pruritus or alopecia occurring beyond the treated area has been documented.
• Gastrointestinal signs: Brief episodes of excessive salivation, attributable primarily to the carrier excipient if the dog licks the wet application site. Vomiting has been reported infrequently.
• Systemic signs: Very rarely, reversible neurological responses including heightened reactivity to stimuli, behavioral depression, and respiratory changes have been observed. These signs typically subside without clinical intervention.

If reactions intensify or fail to resolve within 48 hours, discontinue treatment and seek veterinary advice. Report adverse events to Boehringer Ingelheim’s veterinary pharmacovigilance line.