Simparica Trio Chewable Tablets for Dogs is used to prevent and treat various parasitic infections. The active ingredients in Simparica Trio are sarolaner, moxidectin, and pyrantel.
Sarolaner is an insecticide that kills fleas and ticks, including the American dog tick, the brown dog tick, the Lone Star tick, and the black-legged tick. Moxidectin is an antiparasitic drug that kills heartworm larvae, as well as certain types of intestinal worms. Pyrantel is also an antiparasitic drug that is used to treat and prevent roundworms and hookworms.
Simparica Trio is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the treatment and control of adult hookworms (Ancylostoma caninum and Uncinaria stenocephala), adult roundworms (Toxocara canis and Toxascaris leonina), adult whipworms (Trichuris vulpis), and fleas (Ctenocephalides felis), and for the treatment and control of tick infestations (Amblyomma americanum, Dermacentor variabilis, Ixodes scapularis, and Rhipicephalus sanguineus).
How to use?
To use Simparica Trio for dogs, simply give your dog the appropriate dosage based on their weight as directed by your veterinarian. The chewable tablet should be given orally once a month, with or without food.
It’s important to ensure that your dog has swallowed the entire tablet, and you should observe your dog for several minutes after administration to make sure they do not spit it out.
Simparica Trio weight ranges
|2.8-5.5 LBS (1.25-2.5 Kg)
|5.5-11 LBS (2.6-5 Kg)
|11-22 LBS (5.1-10 Kg)
|22-44 LBS (10.1-20 Kg)
|44-88 LBS (20.1-40 Kg)
|88-132 LBS (40.1-60 Kg)
|>132 LBS (>60 Kg)
|Administer the appropriate combination of tablets
How does Simparica Trio Chewable Tablets for Dogs work?
Simparica Trio works by utilizing three active pharmaceutical ingredients: sarolaner, moxidectin, and pyrantel pamoate. Sarolaner, which is an insecticide and acaricide belonging to the isoxazoline group, inhibits the function of the gamma aminobutyric acid (GABA) and glutamate receptors in insects and acarines. This results in uncontrolled neuromuscular activity leading to death.
Moxidectin, on the other hand, is an endoectocide in the macrocyclic lactone class that interferes with the chloride channel-mediated neurotransmission in parasites. This leads to paralysis and death of the parasite.
Lastly, pyrantel pamoate is a nematocide that belongs to the tetrahydropyrimidine class. It acts as a neuromuscular-blocking agent in susceptible parasites by causing paralysis and death or expulsion of the organism.
IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.
FAQ about Simparica Trio chewable tablets for dogs
Q: What types of parasites does Simparica Trio protect against?
A: Simparica Trio is a combination medication that provides comprehensive protection against a variety of parasites in dogs, including fleas, ticks, heartworms, hookworms, roundworms, and whipworms.
Q: How often should I give my dog Simparica Trio?
A: Simparica Trio is a monthly treatment, so you should give your dog one chewable tablet once every 30 days. It’s important to follow your veterinarian’s dosing instructions carefully, based on your dog’s weight and health status.
Q: Is Simparica Trio safe for all dogs?
A: Simparica Trio is generally safe for use in dogs of all breeds and sizes. Some dogs may experience side effects, such as vomiting, diarrhea, lethargy, and decreased appetite. If you notice any adverse reactions in your dog, you should contact your veterinarian immediately.
Q: How long does it take for Simparica Trio to start working?
A: Simparica Trio Chewable Tablets for Dogs starts working quickly to kill fleas and ticks, with a fast-acting formula that begins to work within hours of administration. It also provides long-lasting protection against heartworms, hookworms, roundworms, and whipworms.
Q: Can Simparica Trio be given to pregnant or nursing dogs?
A: The safety of Simparica Trio has not been established in pregnant or nursing dogs, so it is best to consult with your veterinarian before administering this medication to a pregnant or nursing dog.
Q: Can Simparica Trio for dogs be given with food?
A: Yes, Simparica Trio can be given with or without food, depending on your dog’s preferences. However, it’s important to follow the dosing instructions carefully, based on your dog’s weight and health status.
Q: Is Simparica Trio effective against all types of ticks?
A: Simparica Trio is effective against a variety of ticks, including the American dog tick, the brown dog tick, the Lone Star tick, and the black-legged tick. However, it may not be effective against all species of ticks, so it’s important to talk to your veterinarian about the best tick prevention strategies for your dog.
Q: How should I store Simparica Trio Chewable Tablets for Dogs?
A: Simparica Trio should be stored in a cool, dry place at room temperature (below 86°F/30°C). It should be kept out of reach of children and pets.
Q: Can Simparica Trio be used in conjunction with other medications?
A: Simparica Trio may interact with certain medications, so it’s important to tell your veterinarian about any other medications or supplements your dog is taking before starting treatment with Simparica Trio. Your veterinarian can help determine if it’s safe to use Simparica Trio in conjunction with other medications.
Q: What should I do if my dog misses a dose of Simparica Trio?
A: If your dog misses a dose of Simparica Trio, you should give them the missed dose as soon as possible. If it has been more than 30 days since the last dose, you should start the medication again and consult with your veterinarian about the best dosing schedule for your dog.
Q: Can Simparica Trio be used in puppies?
A: Simparica Trio is indicated for use in dogs that are at least 8 weeks of age and weigh at least 2.8 pounds.
Q: Can Simparica Trio be used on cats or other animals?
A: Simparica Trio is formulated specifically for dogs and should not be used on cats or other animals. It’s important to talk to your veterinarian about the best parasite prevention strategies for your cat or other pets.
Q: What are the weight ranges for Simparica?
A: To make dosing easy, it’s available for dogs in six sizes based on body weight range: Simparica trio for large dogs(Green: 44.1–88 Lbs), very large dogs (Brown: 88.1–132 Lbs), medium dogs(Blue: 22.1–44 Lbs), small dogs(Caramel: 11.1–22 Lbs), extra small dogs(Purple: 5.6–11 lbs), puppies(Gold: 2.8–5.5 Lbs).