Simparica Trio is an advanced parasitic treatment for dogs, targeting fleas, ticks, heartworms, and roundworms. Safe for puppies as young as 8 weeks old and weighing at least 2.8 pounds, it provides comprehensive protection with a single monthly dose. This treatment demonstrates 100% effectiveness against heartworm disease after one dose. It begins killing fleas within 4 hours, achieving full efficacy by 8 hours, and is ≥98.9% effective against tick infestations within 48 hours. Additionally, it boasts 99.2% efficacy against adult roundworms with a notable reduction in fecal egg count and over 94% efficacy against hookworms. Regular monthly administration ensures your dog remains safe and healthy, free from harmful parasites.
Simparica Trio contains three active pharmaceutical ingredients: sarolaner, moxidectin and pyrantel pamoate. Sarolaner works by inhibiting neurotransmitters in parasites, leading to their death. Moxidectin interferes with the parasite’s nerve transmission, effectively preventing heartworm. Pyrantel causes spastic paralysis in worms, which helps in treating intestinal worms.
Directions
- Check the weight of your dog before commencing treatment.
- Directly give the Simparica Trio chewable tablet to your dog or mix it with the dog’s meal.
- Ensure your dog consumes the entire Simparica Trio dose.
- Do not split the Simparica Trio tablet; administer it whole.
- Dosage starts with a minimum dose of 11.4 mg/lb (25 mg/kg) of body weight.
- Treatment with Simparica Trio can begin at any time during the year.
Dosage
Administer Simparica according to the following dosage table.
| Dog’s Weight (lbs) | Simparica Trio Tablet Strength (mg) | Pack Color |
| 2.8 – 5.5 | 6 mg Sarolaner / 0.12 mg Moxidectin / 25 mg Pyrantel | Yellow |
| 5.6 – 11.0 | 12 mg Sarolaner / 0.24 mg Moxidectin / 50 mg Pyrantel | Purple |
| 11.1 – 22.0 | 24 mg Sarolaner / 0.48 mg Moxidectin / 100 mg Pyrantel | Orange |
| 22.1 – 44.0 | 48 mg Sarolaner / 0.96 mg Moxidectin / 200 mg Pyrantel | Green |
| 44.1 – 88.0 | 96 mg Sarolaner / 1.92 mg Moxidectin / 400 mg Pyrantel | Blue |
| 88.1 – 132.0 | 144 mg Sarolaner / 2.88 mg Moxidectin / 600 mg Pyrantel | Brown |
Benefits
- Trusted monthly heartworm preventive: Helps protect dogs from heartworm disease when given every month as directed.
- Fast flea treatment & prevention: Kills adult fleas and helps prevent flea infestations by stopping flea reproduction before it starts.
- Broad-spectrum tick protection: Kills multiple common tick species to support protection against tick exposure.
- Treats common intestinal worms: Controls and treats roundworms and hookworms commonly found in dogs.
- Easy once-monthly chewable tablet: One chew per month simplifies parasite prevention-no separate flea or heartworm meds needed.
- Palatable chew dogs accept easily: Flavored chew designed to make monthly dosing stress-free for pet owners.
- For puppies and adult dogs by weight: Approved for dogs 8 weeks and older, weighing at least 2.8 lbs, available in multiple size-based options.
Safety
- Simparica Trio is strictly recommended for veterinary use only.
- Keep the product away from children.
- Do not eat, drink, or smoke while administering the product.
- After treatment, immediately wash your hands with soap and water.
- Store at a controlled room temperature of 59-86° F (15-30° C).
Warnings:
- Before starting the treatment, consult your vet if your dog has a history of epilepsy, seizures, ataxia, or muscle tremors.
- If your dog experiences vomiting, diarrhea, lethargy, decreased appetite, flatulence, or polydipsia, contact a vet immediately.
Frequently Asked Questions
- What is Simparica Trio and how does it work?
Simparica Trio is a once-monthly chewable tablet that provides “all-in-one” protection. It contains Sarolaner (for fleas/ticks), Moxidectin (for heartworm), and Pyrantel (for intestinal worms). It works by entering the bloodstream; when parasites bite or attach, the active ingredients paralyze their nervous system, causing death.
- How soon after giving Simparica Trio will it start working?
It starts killing fleas within 4 hours and begins killing ticks within 8 hours of the first dose.
- Does Simparica Trio kill existing fleas on dogs?
Yes. It effectively kills existing adult fleas on your dog’s body shortly after administration, helping to break the infestation cycle.
- How long does Simparica Trio protect my dog after a dose?
One tablet provides full, continuous protection for 35 days.
- How does Simparica Trio compare to other flea and heartworm preventatives?
While older products like Heartgard or NexGard only cover one or two categories, Simparica Trio is a single-pill solution that covers internal and external parasites simultaneously, offering better convenience and broader protection.
- Can Simparica Trio prevent heartworm disease?
Yes. It is 100% effective in preventing heartworm disease by killing the larvae transmitted by mosquitoes before they reach the heart.
- What types of ticks does Simparica Trio protect against?
It is FDA-labeled to kill 5 common U.S. species:
- Deer Tick (Black-legged tick)
- American Dog Tick
- Lone Star Tick
- Brown Dog Tick
- Gulf Coast Tick
- Does Simparica Trio prevent Lyme disease?
Yes. By killing the Deer Tick quickly, it prevents the transmission of Borrelia burgdorferi, the bacteria that causes Lyme disease.
- What worms does Simparica Trio treat and prevent?
It treats and prevents Heartworms, Roundworms, and Hookworms.
- How often should I give my dog Simparica Trio?
You should administer it once every month (every 30 days) on a consistent schedule.
- Can Simparica Trio be given with or without food?
Either. It is a liver-flavored chewable that can be given as a treat or mixed into food without affecting its absorption.
- Can Simparica Trio be used year-round?
Yes. We recommend continuous 12-month protection. Ticks and mosquitoes can emerge during warm spells in winter, so seasonal protection is often insufficient.
- What should I do if my dog vomits after taking Simparica Trio?
If vomiting occurs within 3 hours of dosing, the pill likely wasn’t absorbed. Contact your vet to see if a replacement dose is necessary.
- What happens if I miss a dose of Simparica Trio?
Give the missed dose as soon as you remember, then reset your 30-day schedule from that day. Do not double the dose. If a dose is more than eight weeks overdue, a veterinary consultation is essential. Because heartworms take six months to become detectable, your vet will need to establish an appropriate testing and prevention schedule.
- Is Simparica Trio safe for puppies? If so, from what age?
It is safe for puppies from 8 weeks of age who weigh at least 2.8 lbs.
- Do I need a heartworm test before starting Simparica Trio?
Yes. This is a critical safety step. Giving this medication to a heartworm-positive dog can cause a dangerous allergic-like reaction as the larvae die off rapidly.
- Are there any common side effects of Simparica Trio?
Most dogs tolerate it well. Rare side effects include vomiting, diarrhea, lethargy, or loss of appetite.
- Is Simparica Trio safe for all dog breeds?
Generally, yes. It has been tested safely across various breeds, including those with the MDR1 mutation (like Collies), though dogs with a history of seizures should be monitored closely as it belongs to the isoxazoline class.
- Can I use Simparica Trio with other vet medications?
Yes. Clinical trials have shown no adverse interactions between Simparica Trio and common medications such as vaccines, antibiotics, or anti-inflammatories. However, it’s crucial to inform your vet about any other treatments your dog is receiving to ensure the safest and most effective care for your pet.
- Can Simparica Trio be administered to pregnant or lactating dogs?
Safety has not been established for breeding, pregnant, or lactating dogs. I recommend consulting your vet for an alternative during this time.
- Is a prescription required to buy Simparica Trio at AnipetShop?
No, a prescription is not required when purchasing Simparica Trio from AnipetShop. The product is shipped directly from Australia, where Simparica Trio is legally available without a prescription.
- Is the Simparica Trio sold OTC the same product?
Yes. The active ingredients, formulation, and manufacturer are the same.
The difference lies in how each country regulates veterinary medicines, not in product quality or strength.
- Is it safe to use Simparica Trio without a prescription?
While a prescription may not be required in some regions, Simparica Trio is still a potent systemic medication.
Veterinarians generally recommend that dogs:
- Have a recent heartworm test
- Are dosed accurately based on body weight
- Are monitored for side effects after administration